抗结核药物与唑类药物体外抗荚膜组织胞浆菌的协同作用。
Synergistic effect of antituberculosis drugs and azoles in vitro against Histoplasma capsulatum var. capsulatum.
机构信息
Federal University of Ceará, Campus do Porangabussu, Rua Cel. Nunes de Melo, 1315, Rodolfo Teófilo, CEP 60430-275 Fortaleza, Ceará, Brazil.
出版信息
Antimicrob Agents Chemother. 2011 Sep;55(9):4482-4. doi: 10.1128/AAC.01471-10. Epub 2011 Jun 20.
Abstract
This study evaluated in vitro interactions of antituberculosis drugs and triazoles against Histoplasma capsulatum. Nine drug combinations, each including an antituberculosis drug (isoniazid, pyrazinamide, or ethambutol) plus a triazole (itraconazole, fluconazole, or voriconazole), were tested against both growth forms of H. capsulatum. Stronger synergistic interactions were seen in isoniazid or pyrazinamide plus triazoles for the mold form and ethambutol plus voriconazole for the yeast-like form. Further studies should evaluate these combinations in vivo.
摘要
本研究评估了抗结核药物和三唑类药物对荚膜组织胞浆菌的体外相互作用。对 9 种药物组合（每种组合均包括一种抗结核药物（异烟肼、吡嗪酰胺或乙胺丁醇）加一种三唑类药物（伊曲康唑、氟康唑或伏立康唑））进行了测试，以评估它们对荚膜组织胞浆菌的两种生长形式的作用。对于霉菌形式，异烟肼或吡嗪酰胺加三唑类药物表现出更强的协同相互作用，而对于酵母样形式，则是乙胺丁醇加伏立康唑。应进一步研究这些组合在体内的作用。
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