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Antimicrob Agents Chemother. 2010 Sep;54(9):3978-9. doi: 10.1128/AAC.00793-10. Epub 2010 Jun 21.
2
Chapter 4--histoplasmosis.第四章--组织胞浆菌病。
J Bras Pneumol. 2009 Nov;35(11):1145-51. doi: 10.1590/s1806-37132009001100013.
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In vitro synergistic effects of antituberculous drugs plus antifungals against Coccidioides posadasii.抗结核药物联合抗真菌药物对波萨达斯球孢子菌的体外协同作用。
Int J Antimicrob Agents. 2009 Sep;34(3):278-80. doi: 10.1016/j.ijantimicag.2009.04.009. Epub 2009 Jun 10.
4
Detection of Histoplasma capsulatum antigen in Panamanian patients with disseminated histoplasmosis and AIDS.巴拿马播散性组织胞浆菌病合并艾滋病患者中荚膜组织胞浆菌抗原的检测
Clin Vaccine Immunol. 2008 Apr;15(4):681-3. doi: 10.1128/CVI.00358-07. Epub 2008 Feb 20.
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Disseminated histoplasmosis with hemophagocytic syndrome in a patient with AIDS: description of one case and review of the Spanish literature.艾滋病患者并发播散性组织胞浆菌病伴噬血细胞综合征：1例病例描述及西班牙文献综述
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Clinical practice guidelines for the management of patients with histoplasmosis: 2007 update by the Infectious Diseases Society of America.组织胞浆菌病患者管理临床实践指南：美国传染病学会2007年更新版
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In vitro inhibitory effect of antituberculosis drugs on clinical and environmental strains of Coccidioides posadasii.抗结核药物对波萨达斯球孢子菌临床菌株和环境菌株的体外抑制作用。
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Synergy, antagonism, and what the chequerboard puts between them.协同作用、拮抗作用，以及棋盘法介于两者之间的情况。
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In vitro antifungal activity of Micafungin (FK463) against dimorphic fungi: comparison of yeast-like and mycelial forms.米卡芬净（FK463）对双相真菌的体外抗真菌活性：酵母样和菌丝体形式的比较。
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抗结核药物与唑类药物体外抗荚膜组织胞浆菌的协同作用。

Synergistic effect of antituberculosis drugs and azoles in vitro against Histoplasma capsulatum var. capsulatum.

机构信息

Federal University of Ceará, Campus do Porangabussu, Rua Cel. Nunes de Melo, 1315, Rodolfo Teófilo, CEP 60430-275 Fortaleza, Ceará, Brazil.

出版信息

Antimicrob Agents Chemother. 2011 Sep;55(9):4482-4. doi: 10.1128/AAC.01471-10. Epub 2011 Jun 20.

DOI:10.1128/AAC.01471-10
PMID:21690286
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3165363/
Abstract

This study evaluated in vitro interactions of antituberculosis drugs and triazoles against Histoplasma capsulatum. Nine drug combinations, each including an antituberculosis drug (isoniazid, pyrazinamide, or ethambutol) plus a triazole (itraconazole, fluconazole, or voriconazole), were tested against both growth forms of H. capsulatum. Stronger synergistic interactions were seen in isoniazid or pyrazinamide plus triazoles for the mold form and ethambutol plus voriconazole for the yeast-like form. Further studies should evaluate these combinations in vivo.

摘要

本研究评估了抗结核药物和三唑类药物对荚膜组织胞浆菌的体外相互作用。对 9 种药物组合（每种组合均包括一种抗结核药物（异烟肼、吡嗪酰胺或乙胺丁醇）加一种三唑类药物（伊曲康唑、氟康唑或伏立康唑））进行了测试，以评估它们对荚膜组织胞浆菌的两种生长形式的作用。对于霉菌形式，异烟肼或吡嗪酰胺加三唑类药物表现出更强的协同相互作用，而对于酵母样形式，则是乙胺丁醇加伏立康唑。应进一步研究这些组合在体内的作用。