[2 components of the high-threshold calcium current possessing different sensitivities to omega-conotoxin in the membrane of pheochromocytoma cells].
作者信息
Pogorelaia N Kh, Savchenko A N, Verkhratskiĭ A N, Shuba Ia M
出版信息
Neirofiziologiia. 1990;22(3):397-400.
PMID:2169035
Abstract
Blockade of the high-threshold calcium currents by omega-conotoxin (CgTx) was investigated by patch-clamp recordings of whole-cell currents in cultured cells of pheochromocytoma PC12. CgTx (10 mumol/l) preferentially blocked only a steady-state component of the calcium current. Inactivated component was insensitive to CgTx (up to 50 mumol/l concentration). The two component nature of the high-threshold calcium current in pheochromocytoma PC12 cells was suggested.
摘要
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