培养的人神经母细胞瘤细胞中的三种电压依赖性钙电流。
Three types of voltage-dependent calcium currents in cultured human neuroblastoma cells.
作者信息
Kito M, Maehara M, Watanabe K
机构信息
Department of Pediatrics, Chubu Rosai Hospital, Nagoya, Japan.
出版信息
Nagoya J Med Sci. 1995 Mar;58(1-2):29-33.
The voltage-dependent calcium current (ICa) in cultured human neuroblastoma cells (NB-I) was studied by whole-cell recording. The low-threshold current (Il), the high-threshold, fast inactivating current (Ih.f.), and the high-threshold, slow inactivating current (Ih.s.) were identified. Il. was blocked by Ni2+. Ih.f. was blocked by omega-conotoxin GVIA. Ih.s. was blocked by nifedipine, and enhanced by Bay K 8644. These characteristics indicate that Il, Ih.f. and Ih.s. are consistent with the T-, N- and L-type ICa, respectively.
采用全细胞记录法研究了培养的人神经母细胞瘤细胞（NB-I）中的电压依赖性钙电流（ICa）。确定了低阈值电流（Il）、高阈值快速失活电流（Ih.f.）和高阈值缓慢失活电流（Ih.s.）。Il被Ni2+阻断。Ih.f.被ω-芋螺毒素GVIA阻断。Ih.s.被硝苯地平阻断，并被Bay K 8644增强。这些特性表明，Il、Ih.f.和Ih.s.分别与T型、N型和L型ICa一致。
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