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免疫球蛋白 A：下一代治疗性抗体？

Immunoglobulin A: A next generation of therapeutic antibodies?

机构信息

Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands.

出版信息

MAbs. 2011 Jul-Aug;3(4):352-61. doi: 10.4161/mabs.3.4.16092. Epub 2011 Jul 1.

DOI:10.4161/mabs.3.4.16092
PMID:21691145
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3218532/
Abstract

Although immunoglobulin (Ig) A is commonly recognized as the most prevalent antibody subclass at mucosal sites with an important role in mucosal defense, its potential as a therapeutic monoclonal antibody is less well known. However, IgA has multifaceted anti-, non-, and pro-inflammatory functions that can be exploited for different immunotherapeutical strategies, which will be the focus of this review.

摘要

虽然免疫球蛋白 (Ig) A 通常被认为是黏膜部位最常见的抗体亚型，在黏膜防御中具有重要作用，但作为治疗性单克隆抗体的潜力却鲜为人知。然而，IgA 具有多方面的抗炎、非抗炎和促炎功能，可以被用于不同的免疫治疗策略，这将是本综述的重点。

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本文引用的文献

1
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J Immunol. 2011 Jul 15;187(2):726-32. doi: 10.4049/jimmunol.1002581. Epub 2011 Jun 8.
2
Recognition and functional activation of the human IgA receptor (FcalphaRI) by C-reactive protein.C-反应蛋白对人 IgA 受体（FcalphaRI）的识别与功能激活。
Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):4974-9. doi: 10.1073/pnas.1018369108. Epub 2011 Mar 7.
3
Recombinant dimeric IgA antibodies against the epidermal growth factor receptor mediate effective tumor cell killing.针对表皮生长因子受体的重组二聚体 IgA 抗体介导有效的肿瘤细胞杀伤。
J Immunol. 2011 Mar 15;186(6):3770-8. doi: 10.4049/jimmunol.1003082. Epub 2011 Feb 11.
4
Immunization with HIV-1 gp41 subunit virosomes induces mucosal antibodies protecting nonhuman primates against vaginal SHIV challenges.免疫接种 HIV-1 gp41 亚单位病毒体诱导粘膜抗体，保护非人类灵长类动物免受阴道 SHIV 挑战。
Immunity. 2011 Feb 25;34(2):269-80. doi: 10.1016/j.immuni.2011.01.015.
5
A novel human IgA monoclonal antibody protects against tuberculosis.一种新型人 IgA 单克隆抗体可预防结核病。
J Immunol. 2011 Mar 1;186(5):3113-9. doi: 10.4049/jimmunol.1003189. Epub 2011 Jan 21.
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Mucosal Immunol. 2010 Nov;3(6):610-21. doi: 10.1038/mi.2010.38. Epub 2010 Jul 14.
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The role of IgA and IgA Fc receptors as anti-inflammatory agents.IgA 和 IgA Fc 受体作为抗炎剂的作用。
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Deglycosylation of FcalphaR at N58 increases its binding to IgA.FcαR 的 N58 位糖基化缺失使其增加与 IgA 的结合。
Glycobiology. 2010 Jul;20(7):905-15. doi: 10.1093/glycob/cwq048. Epub 2010 Apr 8.
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