Senba M, Buziba N, Mori N, Morimoto K, Nakamura T
Department of Pathology, Institute of Tropical Medicine, Nagasaki University, Japan.
Acta Virol. 2011;55(2):161-4. doi: 10.4149/av_2011_02_161.
Kaposi΄s sarcoma (KS) had been endemic in Africa before the appearance of human immunodeficiency viruses (HIV) in 1985. Incidence of African KS has increased over the time and the risk of contracting KS become greater in HIV-positive as opposed to HIV-negative individuals. KS specimens were collected in 1981-2000 from 228 surgical cases originating from a KS-endemic area of Western Kenya and examined for Kaposi΄s sarcoma-associated herpesvirus (KSHV) by an immunoperoxidase assay. The results showed that the specimens from 1981-1985 (before the HIV epidemic) were KSHV-positive in 10.3% in contrast to the KSHV positivity of 50.1-63.5% in 1986-2000. The linear increase of KSHV positivity in 1981-2000 was statistically significant. The most plausible explanation for the increased prevalence of KSHV in KS cases is that the endemic KS has changed to the epidemic one.
在1985年人类免疫缺陷病毒（HIV）出现之前，卡波西肉瘤（KS）在非洲呈地方性流行。随着时间的推移，非洲KS的发病率有所上升，与HIV阴性个体相比，HIV阳性个体感染KS的风险更高。1981年至2000年期间，从肯尼亚西部KS流行地区的228例手术病例中收集了KS标本，并通过免疫过氧化物酶测定法检测了卡波西肉瘤相关疱疹病毒（KSHV）。结果显示，1981年至1985年（HIV流行之前）的标本中KSHV阳性率为10.3%，而1986年至2000年的KSHV阳性率为50.1% - 63.5%。1981年至2000年期间KSHV阳性率的线性增加具有统计学意义。KS病例中KSHV患病率增加的最合理的解释是地方性KS已转变为流行性KS。
