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免疫神经病变的新型治疗方法即将出现。

Novel treatment for immune neuropathies on the horizon.

机构信息

Department of Neurology, Heinrich-Heine-University, Düsseldorf, Germany MRC Neuromuscular Disease Centre, Institute of Neurology, University College London, London, UK.

出版信息

J Peripher Nerv Syst. 2011 Jun;16(2):75-83. doi: 10.1111/j.1529-8027.2011.00334.x.

Abstract

Immune neuropathies represent a heterogeneous spectrum of acute and chronic peripheral nerve disorders of autoimmune origin. Despite the current available treatment options, immune neuropathies are still associated with severe neurological deficits and poor clinical prognosis. However, during the last years, significant advances have been made in unraveling some of the underlying pathomechanisms. The exploration of novel therapeutic approaches including monoclonal antibodies and oral immunosuppressants, known from other autoimmune disorders such as multiple sclerosis, suggests new approaches to treatment. Here, we review the available clinical data as well as the scientific rationale and expected benefits and risks for these strategies.

摘要

免疫性神经病变代表了一组具有异质性的急性和慢性自身免疫性周围神经疾病。尽管目前有多种治疗选择,但免疫性神经病变仍与严重的神经功能缺损和不良的临床预后相关。然而,在过去的几年中,人们在阐明一些潜在的发病机制方面取得了重大进展。探索新的治疗方法,包括单克隆抗体和口服免疫抑制剂,这些方法在多发性硬化等其他自身免疫性疾病中已有应用,为治疗提供了新的思路。在这里,我们回顾了这些策略的现有临床数据以及科学依据、预期获益和风险。

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