Glišić Radmila, Koko Vesna, Cvijić Gordana, Milošević Maja Čakić, Obradović Jasmina
Institute of Biology and Ecology Faculty of Science, University of Kragujevac, 34000 Kragujevac, Republic of Serbia.
Regul Pept. 2011 Nov 10;171(1-3):6-10. doi: 10.1016/j.regpep.2011.05.012. Epub 2011 Jun 25.
The aim of this study was to investigate the morphological, immunohistochemical and ultrastructural changes of cholecystokinin-producing (I) cells of gastrointestinal mucosa in dexamethasone-treated rats (D). After 12-daily intraperitoneal administration of 2mg/kg dexamethasone, rats developed diabetes similar to human diabetes mellitus type 2. The mean diameter of the duodenum was significantly decreased due to significant reduction of volume fraction and profile area of lamina propria. There was a decrease in volume fraction and number of cholecystokinin (CCK)-producing cells per mm(2) of mucosa, as well as their numerical density, but without statistical significance. Also, dexamethasone induced appearance of hyperactive duodenal I-cells with small number of granules and dilated endoplasmic reticulum. In conclusion, the present study showed that morphological changes in duodenum cholecystokinin-producing (I) cells occurred in diabetic rats, in a manner which, suggests compensatory effort of CCK cells in diabetic condition.
