助溶剂在片剂中阿司匹林含量测定中的新应用

Novel application of hydrotropic solubilizing additives in the estimation of aspirin in tablets.

作者信息

Maheshwari R K, Saxena M, Gahlot M, Chaki R, Kinariwala M, Jagwani Y

机构信息

Department of Pharmacy, S. G. S. I. T. S., 23 Park Road, Indore-452 003, India.

出版信息

Indian J Pharm Sci. 2010 Sep;72(5):649-51. doi: 10.4103/0250-474X.78539.

DOI:10.4103/0250-474X.78539

PMID:21695002

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3116315/

Abstract

Highly concentrated aqueous solutions of various hydrotropic agents like sodium benzoate, sodium salicylate, sodium acetate, sodium citrate, nicotinamide and sodium ascorbate have been observed to enhance aqueous solubilities of a large number of poorly water-soluble drugs. In the present investigation hydrotropic solubilization technique has been employed to solubilize poorly water-soluble aspirin (analgesic and antipyretic drug) by 0.5 M ibuprofen sodium solution to carry out titrimetric analysis of aspirin in tablet dosage form. Results of analysis by proposed method and Phamacopoeial method are very comparable. Proposed method is new, rapid, simple, accurate, and reproducible. Statistical data proved the accuracy, reproducibility and the precision of proposed method.

摘要

已观察到多种助溶剂（如苯甲酸钠、水杨酸钠、醋酸钠、柠檬酸钠、烟酰胺和抗坏血酸钠）的高浓度水溶液可提高大量难溶性药物的水溶性。在本研究中，采用助溶增溶技术，用0.5M布洛芬钠溶液溶解难溶性阿司匹林（止痛和解热药物），以对片剂剂型中的阿司匹林进行滴定分析。所提出方法与药典方法的分析结果具有高度可比性。所提出的方法新颖、快速、简单、准确且可重复。统计数据证明了所提出方法的准确性、可重复性和精密度。