Abraham Sindhu, Deveswaran Rajamanickam, Furtado Sharon, Bharath Srinivasan, Madhavan Varadharajan
Department of Pharmaceutics, M.S. Ramaiah College of Pharmacy, MSRIT Post, MSR Nagar, Bangalore 560054, India.
Department of Pharmacognosy, M.S. Ramaiah College of Pharmacy, MSRIT Post, MSR Nagar, Bangalore 560054, India.
Int Sch Res Notices. 2014 Oct 29;2014:810128. doi: 10.1155/2014/810128. eCollection 2014.
Lornoxicam is a selective cyclooxygenase-1 and cyclooxygenase-2 inhibitor that exhibits anti-inflammatory, analgesic, and antipyretic activities. It is used in osteoarthritis and rheumatoid arthritis; and in treatment of postoperative pain and primary dysmenorrhoea. Lornoxicam is completely insoluble in water but soluble in alkaline solutions. Hydrotropic solubilization is a technique used to increase the aqueous solubility of poorly water-soluble drugs and the present study was aimed at developing a hydrotropic technique to increase the solubility of lornoxicam, using 2 M sodium benzoate as the hydrotropic agent. Beer's law was obeyed in the concentration range of 4-24 μg/mL at 381 nm. The solubility of lornoxicam in distilled water considerably increased with the addition of a hydrotropic agent. The analysis of tablets indicated good correlation between the amounts estimated and label claim. The LOD and LOQ of lornoxicam were found to be 0.34 μg/mL and 1.038 μg/mL, respectively, indicating good sensitivity of the proposed method. The percentage recovery was found to be 99.99%-100.21%. Thus the proposed method is new, simple, environmentally friendly, accurate, and cost effective and can be successfully employed in routine analysis of lornoxicam in tablets.
氯诺昔康是一种选择性环氧化酶 -1 和环氧化酶 -2 抑制剂，具有抗炎、镇痛和解热活性。它用于骨关节炎和类风湿性关节炎；以及治疗术后疼痛和原发性痛经。氯诺昔康在水中完全不溶，但可溶于碱性溶液。助溶是一种用于增加难溶性药物水溶性的技术，本研究旨在开发一种助溶技术，以 2 M 苯甲酸钠作为助溶剂来增加氯诺昔康的溶解度。在 381 nm 波长下，4 - 24 μg/mL 的浓度范围内符合比尔定律。加入助溶剂后，氯诺昔康在蒸馏水中的溶解度显著增加。片剂分析表明，测定量与标签标示量之间具有良好的相关性。氯诺昔康的检测限和定量限分别为 0.34 μg/mL 和 1.038 μg/mL，表明该方法具有良好的灵敏度。回收率为 99.99% - 100.21%。因此，该方法新颖、简单、环保、准确且具有成本效益，可成功用于片剂中氯诺昔康的常规分析。
