Pourzand Ali, Fakhree M Bassir A, Hashemzadeh Shahryar, Halimi Monireh, Daryani Amir
Department of General Surgery, Imam Reza Hospital, Tabriz University of Medical Sciences, Iran.
Breast Cancer (Auckl). 2011;5:87-92. doi: 10.4137/BCBCR.S7199. Epub 2011 May 18.
Increasing evidence shows the importance of young age, estrogen receptor (ER), progesterone receptor (PR) status, and HER-2 expression in patients with breast cancers.
We organized an analytic cross-sectional study of 105 women diagnosed with breast cancer who have been operated on between 2008 to 2010. We evaluated age, size, hormone receptor status, HER-2 and P53 expression as possible indicator of lymph node involvement.
There is a direct correlation between positive progesterone receptor status and being younger than 40 (P < 0.05). Also, compared with older women, young women had tumors that were more likely to be large in size and have higher stages (P < 0.05). Furthermore patients with negative progesterone receptor status were more likely to have HER-2 overexpression (P < 0.05). The differences in propensity to lymph node metastasis between hormone receptor statuses were not statically significant.
Although negative progesterone receptor tumors were more likely to have HER-2 overexpression, it is possible that higher stage and larger size breast cancer in younger women is related to positive progesterone receptor status.
越来越多的证据表明年龄、雌激素受体（ER）、孕激素受体（PR）状态以及HER-2表达在乳腺癌患者中具有重要意义。
我们组织了一项分析性横断面研究，研究对象为2008年至2010年间接受手术治疗的105例确诊为乳腺癌的女性。我们评估了年龄、肿瘤大小、激素受体状态、HER-2和P53表达，将其作为淋巴结受累的可能指标。
孕激素受体状态阳性与年龄小于40岁之间存在直接相关性（P < 0.05）。此外，与老年女性相比，年轻女性的肿瘤更有可能体积较大且分期较高（P < 0.05）。此外，孕激素受体状态为阴性的患者更有可能出现HER-2过表达（P < 0.05）。激素受体状态之间淋巴结转移倾向的差异无统计学意义。
尽管孕激素受体阴性的肿瘤更有可能出现HER-2过表达，但年轻女性中较高分期和较大体积的乳腺癌可能与孕激素受体状态阳性有关。
