• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Involvement of NMDA receptors in non-convulsive epilepsy in WAG/Rij rats.

作者信息

Peeters B W, van Rijn C M, Vossen J M, Coenen A M

机构信息

Department of CNS Pharmacology, Organon International B.V., Oss, The Netherlands.

出版信息

Life Sci. 1990;47(6):523-9. doi: 10.1016/0024-3205(90)90612-u.

DOI:10.1016/0024-3205(90)90612-u
PMID:2169562
Abstract

The involvement of the NMDA receptor in spontaneous non-convulsive epilepsy was studied by intracerebroventricular injections of APH and NMDA in WAG/Rij rats. The WAG/Rij rat strain is recognized as an animal model for human absence epilepsy. EEG registrations showed that APH (5 nmol/5 microliters; 25 nmol/5 microliters; 50 nmol/5 microliters) causes a dose-dependent decrease in the number and mean duration of the spike-wave discharges, while NMDA (50 pmol/5 microliters; 500 pmol/5 microliters; 5 nmol/5 microliters) induces a dose-dependent increase in the number. The effects of NMDA (5 nmol/5 microliters) can be blocked completely by APH (50 nmol/5 microliters). These results suggest an involvement of the NMDA receptor in experimental non-convulsive epilepsy, observed in the WAG/Rij model.

摘要

相似文献

1
Involvement of NMDA receptors in non-convulsive epilepsy in WAG/Rij rats.
Life Sci. 1990;47(6):523-9. doi: 10.1016/0024-3205(90)90612-u.
2
CNQX, a new non-NMDA receptor antagonist, reduces spike wave discharges in the WAG/Rij rat model of absence epilepsy.新型非NMDA受体拮抗剂CNQX可减少失神癫痫WAG/Rij大鼠模型中的棘波放电。
Epilepsy Res. 1991 Jul;9(2):127-31. doi: 10.1016/0920-1211(91)90023-9.
3
The WAG/Rij rat model for nonconvulsive absence epilepsy: involvement of nonNMDA receptors.用于非惊厥性失神癫痫的WAG/Rij大鼠模型：非NMDA受体的作用
Brain Res Bull. 1994;33(6):709-13. doi: 10.1016/0361-9230(94)90236-4.
4
Interactions between NMDA and nonNMDA receptors in nonconvulsive epilepsy in the WAG/Rij inbred strain.WAG/Rij近交系非惊厥性癫痫中NMDA受体与非NMDA受体之间的相互作用
Brain Res Bull. 1994;33(6):715-8. doi: 10.1016/0361-9230(94)90237-2.
5
Effect of NMDA and 2-amino-7-phosphonoheptanoate focal injection into the ventrolateral thalamic nucleus on the high pressure neurological syndrome in the rat.
Brain Res. 1990 Jan 22;507(2):354-6. doi: 10.1016/0006-8993(90)90298-p.
6
N-Methyl-D-aspartate and L-aspartate activate distinct receptors in piriform cortex.N-甲基-D-天冬氨酸和L-天冬氨酸激活梨状皮质中的不同受体。
Cell Mol Neurobiol. 1984 Jun;4(2):185-90. doi: 10.1007/BF00711004.
7
NMDA-NR1 and AMPA-GluR4 receptor subunit immunoreactivities in the absence epileptic WAG/Rij rat.失神癫痫WAG/Rij大鼠中NMDA-NR1和AMPA-GluR4受体亚基的免疫反应性
Epilepsy Res. 2006 May;69(2):119-28. doi: 10.1016/j.eplepsyres.2006.01.003. Epub 2006 Feb 17.
8
Effects of GABA-ergic agents on spontaneous non-convulsive epilepsy, EEG and behaviour, in the WAG/RIJ inbred strain of rats.γ-氨基丁酸能药物对WAG/RIJ近交系大鼠自发性非惊厥性癫痫、脑电图及行为的影响。
Life Sci. 1989;45(13):1171-6. doi: 10.1016/0024-3205(89)90505-5.
9
The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy.选择性代谢型谷氨酸受体2/3（mGlu2/3）拮抗剂LY341495可降低失神癫痫WAG/Rij大鼠模型中的棘波放电频率。
Neuropharmacology. 2005;49 Suppl 1:89-103. doi: 10.1016/j.neuropharm.2005.05.019.
10
Hypoglycemia-induced neuronal damage prevented by an N-methyl-D-aspartate antagonist.
Science. 1985 Nov 8;230(4726):681-3. doi: 10.1126/science.2996146.

引用本文的文献

1
An In Vivo Electroencephalographic Analysis of the Effect of Riluzole against Limbic and Absence Seizure and Comparison with Glutamate Antagonists.利鲁唑对边缘性发作和失神发作作用的体内脑电图分析及其与谷氨酸拮抗剂的比较
Pharmaceutics. 2023 Jul 22;15(7):2006. doi: 10.3390/pharmaceutics15072006.
2
NMDA Receptor Expression in the Thalamus of the Stargazer Model of Absence Epilepsy.星状突模型失神癫痫丘脑 NMDA 受体表达。
Sci Rep. 2017 Feb 21;7:42926. doi: 10.1038/srep42926.
3
Neurochemical and behavioral features in genetic absence epilepsy and in acutely induced absence seizures.
遗传性失神癫痫和急性诱发失神发作的神经化学及行为特征。
ISRN Neurol. 2013 May 7;2013:875834. doi: 10.1155/2013/875834. Print 2013.
4
Potentiation of mGlu5 receptors with the novel enhancer, VU0360172, reduces spontaneous absence seizures in WAG/Rij rats.新型增强剂 VU0360172 增强 mGlu5 受体可减少 WAG/Rij 大鼠的自发性失神发作。
Neuropharmacology. 2013 Mar;66:330-8. doi: 10.1016/j.neuropharm.2012.05.044. Epub 2012 Jun 15.
5
Diminished presynaptic GABA(B) receptor function in the neocortex of a genetic model of absence epilepsy.失神癫痫遗传模型新皮质中突触前GABA(B)受体功能减退。
Neurosignals. 2009;17(2):121-31. doi: 10.1159/000197864. Epub 2009 Jan 29.