Peeters B W, Ramakers G M, Ellenbroek B A, Vossen J M, Coenen A M
Department of Neuropharmacology, Organon International B.V., Oss, The Netherlands.
Brain Res Bull. 1994;33(6):715-8. doi: 10.1016/0361-9230(94)90237-2.
The interaction between NMDA and nonNMDA receptors was studied in nonconvulsive epilepsy in WAG/Rij rats. Compounds acting on NMDA (NMDA, APH) and nonNMDA (AMPA, GDEE, kainic acid, kynurenic acid) receptors were coinjected intracerebroventricularly. The WAG/Rij rat strain may be an animal model for human nonconvulsive absence epilepsy. The effects on the epilepsy, EEG and behaviour were measured. It appeared that the epilepsy increase, induced by the nonNMDA receptor agonist AMPA, and in a less obvious way, kainic acid, was blocked by the NMDA receptor antagonist APH. The effects of NMDA were completely blocked by the nonNMDA receptor antagonists GDEE and kynurenic acid. These results suggest that there is an interaction between NMDA and nonNMDA receptors. It might be that nonNMDAergic compounds act via activation or inactivation of NMDA receptors and that this latter receptor subtype is the trigger for an epileptic seizure.
在WAG/Rij大鼠的非惊厥性癫痫中研究了NMDA和非NMDA受体之间的相互作用。将作用于NMDA（NMDA、AP5）和非NMDA（AMPA、GDEE、 kainic acid、犬尿喹啉酸）受体的化合物经脑室内共同注射。WAG/Rij大鼠品系可能是人类非惊厥性失神癫痫的动物模型。测定了对癫痫、脑电图和行为的影响。结果显示，非NMDA受体激动剂AMPA以及作用稍弱的海人酸所诱发的癫痫发作增强，被NMDA受体拮抗剂AP5阻断。NMDA的作用被非NMDA受体拮抗剂GDEE和犬尿喹啉酸完全阻断。这些结果提示，NMDA和非NMDA受体之间存在相互作用。可能是非NMDA能化合物通过激活或失活NMDA受体起作用，而后一种受体亚型是癫痫发作的触发因素。
