Shakur Yasmin, de Koning Harry P, Ke Hengming, Kambayashi Junichi, Seebeck Thomas
Otsuka Maryland Medicinal Laboratories Inc, 9900 Medical Center Drive, Rockville, MD 20850, USA.
Handb Exp Pharmacol. 2011(204):487-510. doi: 10.1007/978-3-642-17969-3_20.
Protozoan parasites of the order kinetoplastida are the causative agents of three of the world's most important neglected human diseases: African trypanosomiasis, American trypanosomiasis, and leishmaniasis. Current therapies are limited, with some treatments having serious and sometimes lethal side effects. The growing number of cases that are refractory to treatment is also of concern. With few new drugs in development, there is an unmet medical need for new, more effective, and safer medications. Recent studies employing genetic and pharmacological techniques have begun to shed light on the role of the cyclic nucleotide phosphodiesterases in the life cycle of these pathogens and suggest that these important regulators of cyclic nucleotide signaling may be promising new targets for the treatment of parasitic diseases.
非洲锥虫病、美洲锥虫病和利什曼病。目前的治疗方法有限，一些治疗方法有严重且有时致命的副作用。越来越多对治疗难治的病例也令人担忧。由于正在研发的新药很少，对新的、更有效且更安全的药物存在未满足的医疗需求。最近采用遗传和药理学技术的研究已开始揭示环核苷酸磷酸二酯酶在这些病原体生命周期中的作用，并表明这些环核苷酸信号的重要调节因子可能是治疗寄生虫病的有前景的新靶点。
