Muangpaisan Weerasak, Mathews Aju, Hori Hiroyuki, Seidel David
Department of Preventive and Social Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
J Med Assoc Thai. 2011 Jun;94(6):749-55.
A number of epidemiologic studies of Parkinson 's disease (PD) have been conducted worldwide over the years. Although every study reported the rise in prevalence and incidence rate of PD with the increasing age, the overall estimates were different across countries. The variation in reported data may partly be contributed by case ascertainment, case finding method, data collection, and most importantly different population structures.
Systematically review prevalence and incidence of PD and find the causes of variation in the results.
A literature search was conducted on Medline and EMBASE for studies worldwide investigating the prevalence and incidence of PD and included all adults, English and publication between 1965 and January 2010. The primary search of both databases yielded 5,330 results. After screening topics and abstracts, 168 relevant abstracts were tagged and saved for more thorough perusal. Ultimately, 40 papers were selected for review after applying the pre-specified inclusion criteria
The worldwide prevalence of PD varies widely. One reason for the variation in prevalence estimates could be due to the differences in survival across countries. The use of epidemiological studies using medical records could be another reason for the variation in disease frequency.
PD is common in the elderly. A number of descriptive epidemiologic studies have been conducted worldwide. Comparing the incidence and prevalence of Parkinson's disease is difficult.
多年来，全球范围内开展了多项帕金森病（PD）的流行病学研究。尽管每项研究都报告了PD的患病率和发病率随年龄增长而上升，但各国的总体估计数有所不同。报告数据的差异可能部分归因于病例确诊、病例发现方法、数据收集，最重要的是不同的人口结构。
系统回顾PD的患病率和发病率，并找出结果差异的原因。
在Medline和EMBASE上进行文献检索，以查找全球范围内调查PD患病率和发病率的研究，纳入所有成年人、英文文献以及1965年至2010年1月期间发表的文献。对这两个数据库的初步检索产生了5330条结果。在筛选主题和摘要后，168篇相关摘要被标记并保存以供更深入研读。最终，在应用预先指定的纳入标准后，选择了40篇论文进行综述。
全球范围内PD的患病率差异很大。患病率估计值存在差异的一个原因可能是各国生存率的差异。使用病历进行流行病学研究可能是疾病频率差异的另一个原因。
PD在老年人中很常见。全球范围内已经开展了多项描述性流行病学研究。比较帕金森病的发病率和患病率很困难。
