Orji Obinna James, Ijioma Chimaobi Ezekiel, Odarah Jeffrey Ehiedu, Okeji Izuchukwu Elvis, Areh Joseph Ekama, Anele Donatus Onyebuchi, Zacs Innocent Chima, Kalesanwo Emmanuel Ayomide, Austin-Jemifor Ochuko, Nnamani Uchenna Chika
Department of Acute Medicine, University Hospital of Derby and Burton, NHS Foundation Trust, Derby, GBR.
Department of Pediatrics, Abia State Specialist Hospital and Diagnostics Centre, Umuahia, NGA.
Cureus. 2024 Jul 22;16(7):e65077. doi: 10.7759/cureus.65077. eCollection 2024 Jul.
Background Parkinson's disease (PD) is a chronic neurodegenerative disorder that significantly impacts patients' quality of life (QoL). Depression is a common comorbidity in patients with PD, potentially exacerbating QoL deterioration. This study aimed to assess the influence of depression on QoL in patients with PD at Ladoke Akintola University of Technology (LAUTECH), Ogbomoso, Nigeria. Methodology A cross-sectional, descriptive study design was utilized. The study included 420 patients with PD attending the Neurology Clinic at LAUTECH. A purposive sampling technique was employed to select participants. Data collection instruments included the Unified Parkinson's Disease Rating Scale (UPDRS) for PD assessment, the Hoehn and Yahr scale for PD staging, the Patient Health Questionnaire-9 (PHQ-9) for depression evaluation, and the Parkinson's Disease Questionnaire-39 (PDQ-39) for QoL assessment. Data were analyzed using SPSS version 25.0 (IBM Corp., Armonk, NY), with descriptive and inferential statistics (Chi-square test) to determine associations, considering a -value < 0.05 as significant. Results Among the participants, the prevalence of moderate to severe depression was 245, representing 58.81%. QoL assessment revealed that 297 (70.71%) patients with PD reported poor to very poor overall QoL. A significant association was found between the degree of depression and overall QoL ( = 0.000). Patients with severe depression reported the poorest QoL, while those with minimal to no depression reported the highest QoL scores. Conclusions Depression significantly impacts the QoL in patients with PD at LAUTECH in southwest Nigeria. Addressing depression in PD management is crucial to improve patient outcomes.
帕金森病（PD）是一种慢性神经退行性疾病，严重影响患者的生活质量（QoL）。抑郁症是PD患者常见的合并症，可能会加剧生活质量的恶化。本研究旨在评估抑郁症对尼日利亚奥贡博索拉多克·阿金托拉科技大学（LAUTECH）PD患者生活质量的影响。方法：采用横断面描述性研究设计。该研究纳入了420名在LAUTECH神经科门诊就诊的PD患者。采用目的抽样技术选择参与者。数据收集工具包括用于PD评估的统一帕金森病评定量表（UPDRS）、用于PD分期的Hoehn和Yahr量表、用于抑郁症评估的患者健康问卷-9（PHQ-9）以及用于生活质量评估的帕金森病问卷-39（PDQ-39）。使用SPSS 25.0版（IBM公司，纽约州阿蒙克）进行数据分析，采用描述性和推断性统计（卡方检验）来确定相关性，将P值<０.05视为具有统计学意义。结果：在参与者中，中度至重度抑郁症的患病率为245例，占58.81%。生活质量评估显示，297例（70.71%）PD患者报告总体生活质量较差至极差。发现抑郁症程度与总体生活质量之间存在显著关联（P = 0.000）。重度抑郁症患者报告的生活质量最差，而轻度至无抑郁症患者报告的生活质量得分最高。结论：在尼日利亚西南部的LAUTECH，抑郁症显著影响PD患者的生活质量。在PD管理中解决抑郁症问题对于改善患者预后至关重要。
