Department of Pedodontics and Preventive Dentistry, Faculty of Dental Sciences of Sri Ramachandra University, Chennai – 600116, India.
Curr Drug Deliv. 2011 Sep;8(5):586-94. doi: 10.2174/156720111796642336.
The present review provides an insight into various potential areas of dentistry that are being invaded by nanotechnology based drugs and drug delivery systems. Current treatments for diseases of dental and oral structures rely on the use of classical pharmacological agents which, in some cases are limited by low efficacy and lack of selectivity to target cells. However, various nanostructures in drug delivery and their challenges in the field of dentistry have not been reviewed so far in the literature. The different treatment opportunities of importance include caries control restorations, tooth remineralisation, management of dentinal hypersensitivity, dental caries vaccine, management of oral biofilm, root canal disinfection, local anaesthesia and periodontal infection. The authors have also identified few dental applications demanding extensive research to emerge as a promising therapeutic strategy. We conclude by claiming that dentistry should follow the trend of probing matter at nanoscale to achieve a predictable treatment outcome.
本综述深入探讨了纳米技术药物和药物输送系统正在涉足的各个潜在牙科领域。目前针对牙齿和口腔结构疾病的治疗依赖于使用经典的药理学制剂，而在某些情况下，这些制剂受到疗效低和缺乏靶向细胞选择性的限制。然而，迄今为止，文献中尚未对药物输送中的各种纳米结构及其在牙科领域的挑战进行综述。重要的不同治疗机会包括龋齿控制修复、牙齿再矿化、牙本质过敏症的管理、龋齿疫苗、口腔生物膜的管理、根管消毒、局部麻醉和牙周感染。作者还确定了一些需要广泛研究的牙科应用，这些应用有望成为一种有前途的治疗策略。我们的结论是，牙科应该遵循在纳米尺度探测物质的趋势，以达到可预测的治疗效果。
