Department of Obstetrics and Gynaecology, Innenstadt, Maistrasse 11, Ludwig-Maximilians-University, 80337 Munich, Germany.
J Reprod Immunol. 2011 Jun;90(1):67-73. doi: 10.1016/j.jri.2011.04.009. Epub 2011 Jun 22.
Capacity to cope with stress is crucial for survival and also reproduction. The stress response differs in the various parts of an organism. Central corticotropin-releasing hormone (CRH) has been identified to be the main stress regulator. In the reproductive system, stress has a deleterious effect on reproduction and CRH is associated with dysfunction of the reproductive endocrine axis. Members of the CRH family have been detected in different reproductive organs of males and females. Ovarian CRH is probably involved in steroid biosynthesis and inflammatory like processes, ovulation and luteolysis. These effects are mediated via the CRH receptors CRH-R1 and CRH-R2. CRH-Rs are G protein-coupled receptors that drive different signalling pathways in the cell. In human, ligands for these receptors are CRH, urocortin 1, stresscopin-related peptide and stresscopin. This review gives an overview on the expression of the CRH family members in the ovary of mammals. Furthermore, potential CRH-induced signalling mechanisms in the ovary will be introduced.
应对压力的能力对生存和繁殖至关重要。生物体的不同部位的应激反应不同。中枢促肾上腺皮质激素释放激素（CRH）已被确定为主要的应激调节剂。在生殖系统中，压力对生殖有有害影响，CRH 与生殖内分泌轴的功能障碍有关。CRH 家族的成员已在男性和女性的不同生殖器官中被检测到。卵巢 CRH 可能参与类固醇生物合成和类似炎症的过程、排卵和黄体溶解。这些作用是通过 CRH 受体 CRH-R1 和 CRH-R2 介导的。CRH-Rs 是 G 蛋白偶联受体，在细胞中驱动不同的信号通路。在人类中，这些受体的配体是 CRH、尿皮质素 1、应激相关肽和应激素。本文综述了 CRH 家族成员在哺乳动物卵巢中的表达。此外，还介绍了卵巢中潜在的 CRH 诱导的信号转导机制。
