Gynecologic Oncology, Washington University School of Medicine, 4911 Barnes Jewish Hospital Plaza, St. Louis, MO 63110, USA.
Cancer Biomark. 2013;13(3):145-54. doi: 10.3233/CBM-130324.
The importance of adrenergic pathways in cancer has long been suspected, but now there is mounting epidemiological, preclinical, and clinical evidence of its importance in gynecologic cancers. To date, most of these effects are mediated primarily through the beta 2 adrenergic receptor activation of the tumor cell cyclic AMP-protein kinase A signaling pathway. This review will discuss the current knowledge about the neuroendocrine stress response in gynecologic tumor biology.
肾上腺素能途径在癌症中的重要性早已被怀疑，但现在有越来越多的流行病学、临床前和临床证据表明其在妇科癌症中的重要性。迄今为止，这些作用主要通过肿瘤细胞环 AMP-蛋白激酶 A 信号通路的β 2 肾上腺素能受体激活来介导。本文将讨论目前关于妇科肿瘤生物学中神经内分泌应激反应的知识。
