Department of Dermatology, Medical University of Vienna, Vienna, Austria.
J Am Acad Dermatol. 2012 Jan;66(1):58-62. doi: 10.1016/j.jaad.2010.09.773. Epub 2011 Jun 22.
Polymorphic light eruption (PLE) is the most common idiopathic photodermatosis. Reactive oxygen species have been implicated in the pathogenesis of PLE. Polypodium leucotomos (PL) is a natural extract from tropical fern leaves with potent antioxidant and anti-inflammatory properties.
In this study we sought to evaluate whether a concentrated hydrophilic extract of PL might prevent or delay the photoinduction of typical PLE lesions by artificial ultraviolet (UV) radiation.
A total of 35 patients with long-standing PLE were included in this open, uncontrolled bicenter study. PLE was induced by photoprovocation with artificial UVB and UVA light, thereafter oral treatment with PL was initiated. Two weeks later a second photoprovocation was performed while the patients were still taking PL.
Thirty patients developed PLE lesions after repeated irradiation with UVA. Of these, 18 patients also responded to UVB. After PL treatment, 9 (30%) and 5 (28%) patients, respectively, were unresponsive to repeated UVA and UVB exposure. In the remaining patients, the mean number of UVA and UVB irradiations required to elicit PLE increased significantly from 1.95 to 2.62 (P = .005) and from 2.38 to 2.92 (P = .047), respectively.
The study was open and uncontrolled and included a relatively small number of patients.
Our data indicate that oral PL treatment might be beneficial for the prevention of PLE.
多形性日光疹（PLE）是最常见的特发性光皮病。活性氧物种被认为与 PLE 的发病机制有关。水飞蓟素（PL）是一种来自热带蕨类植物的天然提取物，具有强大的抗氧化和抗炎特性。
在这项研究中，我们试图评估浓缩亲水性 PL 提取物是否可以预防或延迟人工紫外线（UV）辐射引起的典型 PLE 病变的光诱导。
共有 35 名患有长期 PLE 的患者参加了这项开放、非对照的双中心研究。通过人工 UVB 和 UVA 光进行光激发来诱导 PLE，然后开始口服 PL 治疗。两周后，在患者仍服用 PL 的情况下进行第二次光激发。
30 名患者在重复 UVA 照射后出现 PLE 病变。其中，18 名患者对 UVB 也有反应。PL 治疗后，分别有 9（30%）和 5（28%）名患者对重复 UVA 和 UVB 暴露无反应。在其余患者中，诱发 PLE 的 UVA 和 UVB 照射次数从 1.95 次增加到 2.62 次（P =.005）和从 2.38 次增加到 2.92 次（P =.047），差异均有统计学意义。
该研究是开放和非对照的，且仅纳入了相对较少的患者。
我们的数据表明，口服 PL 治疗可能有益于预防 PLE。
