Kohli Indermeet, Shafi Rubina, Isedeh Prescilia, Griffith James L, Al-Jamal Mohammed S, Silpa-Archa Narumol, Jackson Bradford, Athar Mohammed, Kollias Nikiforos, Elmets Craig A, Lim Henry W, Hamzavi Iltefat H
Multicultural Dermatology Center, Department of Dermatology, Henry Ford Hospital, Detroit, Michigan.
Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama.
J Am Acad Dermatol. 2017 Jul;77(1):33-41.e1. doi: 10.1016/j.jaad.2017.01.044. Epub 2017 Mar 22.
There is a rationale for adding systemic photoprotective agents to the current photoprotection regimen.
This study was designed to objectively evaluate the molecular and photobiologic effects of oral administration of Polypodium leucotomos extract (PLE).
In all, 22 subjects with Fitzpatrick skin phototype I to III were enrolled. On day 1, subjects were irradiated with visible light, ultraviolet (UV) A1, and UVB (using 308-nm excimer laser). Evaluation was done immediately and 24 hours after irradiation. On days 3 and 4, irradiation and evaluation process was repeated after ingestion of PLE.
Clinical assessments and colorimetry data showed a decrease in UVB-induced changes in 17 of 22 subjects post-PLE administration; histology findings demonstrated such a decrease in all 22 subjects.
Only 2 doses of PLE were given. Furthermore, subjects with skin phototypes I to III only were studied.
The results suggest that PLE can potentially be used as an adjunctive agent to lessen the negative photobiologic effects of UVB.
在当前的光防护方案中添加全身性光保护剂是有理论依据的。
本研究旨在客观评估口服白蕨提取物(PLE)的分子和光生物学效应。
总共招募了22名皮肤 Fitzpatrick 分型为 I 至 III 型的受试者。在第1天,让受试者接受可见光、紫外线A1和紫外线B照射(使用308纳米准分子激光)。在照射后立即以及照射后24小时进行评估。在第3天和第4天,在摄入PLE后重复照射和评估过程。
临床评估和比色法数据显示,22名受试者中有17名在服用PLE后紫外线B诱导的变化有所减少;组织学结果表明所有22名受试者均有此类减少。
仅给予了2剂PLE。此外,仅研究了皮肤分型为I至III型的受试者。
结果表明,PLE有可能用作辅助剂以减轻紫外线B的负面光生物学效应。