Ucvet Ahmet, Kul Cemil, Gursoy Soner, Erbaycu Ahmet Emin, Kaya Seyda Ors, Dinc Zekiye Aydogdu, Yucel Nur
Department of Thoracic Surgery, Dr Suat Seren Chest Diseases and Thoracic Surgery Training Hospital, Izmir, Turquía.
Arch Bronconeumol. 2011 Aug;47(8):397-402. doi: 10.1016/j.arbres.2011.04.010. Epub 2011 Jun 22.
Several markers have been investigated to predict the prognosis of lung cancer. In the present study, the prognostic values of epithelial growth factor receptor (EGFR), vascular endothelial growth factor (VEGF), E-cadherin, and p120 catenin expression were investigated by immunohistochemistry in patients with a surgically resected non-small cell lung carcinoma (NSCLC).
EGFR, VEGF, E-cadherin, and p120 catenin expression were prospectively determined in resected specimens from patients with NSCLC who had undergone surgery between 2003 and 2007. Patients' and disease-related general characteristics and survival rate were recorded.
One hundred seventeen patients with a mean age of 61.3 years were included in the study. After a mean follow-up of 27.5 months, the median survival was determined to be 44.0 months and the 5-year survival was 46.2%. The 5-year survival in negative and positive staining groups were as follows; 32% and 66.7% for EGFR (p = 0.02), 37.8% and 50.7% for VEGF (p = 0.5), 41% and 66% for E-cadherin (p = 0.19), 46% and 50% for p120 catenin (p = 0.27). The differentiation, N status, stage and EGFR staining were variables significantly affecting survival (p = 0.001, 0.006, 0.03 and 0.02 respectively). In multivariate Cox analysis, the EGFR staining level and N status were variables those significantly affecting survival (p = 0.021 and p = 0.010).
While negative staining of EGFR was related with poor survival, staining of VEGF, E-cadherin, and p120 catenin were not related with survival in patients with resected NSCLC.
已经对多种标志物进行了研究，以预测肺癌的预后。在本研究中，通过免疫组织化学法对手术切除的非小细胞肺癌（NSCLC）患者的上皮生长因子受体（EGFR）、血管内皮生长因子（VEGF）、E-钙黏蛋白和p120连环蛋白表达的预后价值进行了研究。
前瞻性地测定了2003年至2007年间接受手术的NSCLC患者切除标本中的EGFR、VEGF、E-钙黏蛋白和p120连环蛋白表达。记录患者及疾病相关的一般特征和生存率。
117例平均年龄为61.3岁的患者纳入研究。平均随访27.5个月后，确定中位生存期为44.0个月，5年生存率为46.2%。阴性和阳性染色组的5年生存率如下：EGFR分别为32%和66.7%（p = 0.02），VEGF分别为37.8%和50.7%（p = 0.5），E-钙黏蛋白分别为41%和66%（p = 0.19），p120连环蛋白分别为46%和50%（p = 0.27）。分化程度、N状态、分期和EGFR染色是显著影响生存的变量（分别为p = 0.001、0.006、0.03和0.02）。在多因素Cox分析中，EGFR染色水平和N状态是显著影响生存的变量（p = 0.021和p = 0.010）。
虽然EGFR阴性染色与生存不良相关，但VEGF、E-钙黏蛋白和p120连环蛋白染色与手术切除的NSCLC患者的生存无关。
