Department of Infectious Diseases, Chi Mei Medical Center, Tainan, Taiwan.
J Microbiol Immunol Infect. 2011 Dec;44(6):418-23. doi: 10.1016/j.jmii.2011.04.012. Epub 2011 Jun 22.
Group A streptococcus (GAS) is a common cause of soft tissue infection. Nonsteroidal anti-inflammatory drugs have been reported to worsen GAS soft tissue infections.
A mouse model of GAS soft tissue infection was developed. The extent of cutaneous lesions, tissue damage, release of inflammatory cytokines, and survival rates were compared between mice with and without ibuprofen administration after GAS soft tissue infection.
All twelve mice without ibuprofen administration survived for at least 10 days. In contrast, mortality rate of 14 mice with ibuprofen therapy was 72.5%. Ibuprofen-treated mice exhibited more evident macrophage infiltration and tissue damage in the GAS-infected soft tissues. In GAS-infected mice, tissue levels of interleukin 6 and tumor necrosis factor alpha were significantly higher in ibuprofen-treated mice than those in the control group.
The results supported the concept that ibuprofen use in GAS soft tissue infections might induce the development of severe necrotizing infections and increase mortality rate.
A 组链球菌（GAS）是软组织感染的常见原因。据报道，非甾体抗炎药会使 GAS 软组织感染恶化。
建立了 GAS 软组织感染的小鼠模型。比较了 GAS 软组织感染后给予和不给予布洛芬的小鼠的皮肤损伤程度、组织损伤、炎症细胞因子释放和存活率。
所有 12 只未给予布洛芬的小鼠至少存活了 10 天。相比之下，接受布洛芬治疗的 14 只小鼠的死亡率为 72.5%。在 GAS 感染的软组织中，布洛芬治疗组的巨噬细胞浸润和组织损伤更为明显。在 GAS 感染的小鼠中，布洛芬治疗组的组织中白细胞介素 6 和肿瘤坏死因子 α 的水平明显高于对照组。
这些结果支持了 GAS 软组织感染中使用布洛芬可能会诱导严重坏死性感染并增加死亡率的观点。
