Department of Dermatology, CH Porto EPE - Hospital de Santo António, Porto, Portugal.
Eur J Dermatol. 2011 Sep-Oct;21(5):750-2. doi: 10.1684/ejd.2011.1419.
Frontal fibrosing alopecia (FFA) is a primary lymphocytic cicatricial alopecia with a distinctive clinical pattern of progressive frontotemporal hairline recession.
Our purpose was to describe the clinical and histopathological features as well as the response to treatment of eleven cases of FFA diagnosed at the Trichology Consultation, over three years.
A retrospective case note review was performed of eleven adult patients with FFA. The clinical data as well the histopathologic findings and laboratory tests were accessed. The patients were treated with different drugs, depending on the stage of the disease. The age of onset of the alopecia ranged from 45 to 80 years. Ten patients (90.9%) were postmenopausal women. All patients had progressive and symmetrical alopecia localized to the frontal and temporal hairline. Seven patients (63.6%) had marked decreased to complete loss of eyebrows and in four patients axillar alopecia was also evident. Laboratory investigations were normal. Scalp biopsy specimens from the anterior hairline showed similar findings. No significant improvement was observed in the majority of cases.
Differential diagnosis should take into account several other conditions. It seems there is no effective treatment proven with an appropriate level of evidence in the management of FFA.
额部纤维性脱发（FFA）是一种原发性淋巴细胞性瘢痕性脱发，具有独特的临床模式，表现为额颞部发际线进行性后退。
我们旨在描述在毛发科咨询处诊断的 11 例 FFA 的临床和组织病理学特征以及对治疗的反应。
回顾性病例记录分析了 11 例 FFA 的成年患者。评估了临床资料、组织病理学发现和实验室检查。根据疾病的阶段，采用不同的药物对患者进行治疗。脱发的发病年龄为 45 至 80 岁。10 例患者（90.9%）为绝经后女性。所有患者均有进行性和对称性脱发，局限于额部和颞部发际线。7 例患者（63.6%）眉毛明显减少至完全缺失，4 例患者腋部也有脱发。实验室检查正常。头皮前发际线活检标本显示类似发现。大多数病例未见明显改善。
鉴别诊断应考虑到其他几种情况。对于 FFA 的治疗，似乎没有有效的治疗方法，也没有足够证据证明其有效性。
