Sato Akie, Nakashima Yoko
Department of Human Nutrition, Seitoku University, 550 Iwase, Matsudo, Chiba, Japan.
J Nutr Sci Vitaminol (Tokyo). 2011;57(2):156-61. doi: 10.3177/jnsv.57.156.
Zinc (Zn)-deficiency causes a reduction in food intake and alters adipose metabolism. The effect of zinc restriction in rats on the selection of fish-oil and lard was studied during a period of reduced appetite. The reduction of appetite was caused by an experimentally induced Zn-deficiency. Four-week-old male rats were divided into three dietary treatment groups: Zn-adequate (ZnA, 30.9 mg Zn/kg), marginal Zn-deficient (ZnM, 5.9 mg Zn/kg) or Zn-deficient (ZnD, 0.9 mg Zn/kg). The three groups were placed on a self-selection regimen of the ZnA-fish-oil diet (ZnA-FD) and the ZnA-lard diet (ZnA-LD), the ZnM-FD and the ZnM-LD or the ZnD-FD and the ZnD-LD, respectively for 24 d. The amount of the FD intake in the ZnD group decreased to 0.5 g/d after day 4-6 of self-selecting on the LD and the FD and no significant increase in the FD intake in the group was observed during the self-selection period. However, after day 7-9 and 13-15, the FD intake of the ZnA and the ZnM groups increased, respectively, and at the end of the self-selection period the ZnM and the ZnA rats consumed about 2.0 g FD/d and 4.5 g FD/d, respectively. The FD intake ratio [FD intake (g)/total intake (g)] in the ZnD rats during the self-selection period was the lowest and that in the ZnA rats was the highest of three groups. In conclusion, we showed that zinc status alters fish-oil and lard selection patterns and ZnD rats did not show a preference for fish-oil.
锌（Zn）缺乏会导致食物摄入量减少并改变脂肪代谢。在食欲降低期间，研究了大鼠锌限制对鱼油和猪油选择的影响。食欲降低是由实验性诱导的锌缺乏引起的。将四周龄雄性大鼠分为三个饮食处理组：锌充足组（ZnA，30.9毫克锌/千克）、边缘锌缺乏组（ZnM，5.9毫克锌/千克）或锌缺乏组（ZnD，0.9毫克锌/千克）。三组分别采用锌充足-鱼油饮食（ZnA-FD）和锌充足-猪油饮食（ZnA-LD）、锌边缘缺乏-鱼油饮食（ZnM-FD）和锌边缘缺乏-猪油饮食（ZnM-LD）或锌缺乏-鱼油饮食（ZnD-FD）和锌缺乏-猪油饮食（ZnD-LD）的自选方案，持续24天。在自选猪油和鱼油饮食4-6天后，ZnD组的鱼油摄入量降至0.5克/天，且在自选期间该组鱼油摄入量未观察到显著增加。然而，在第7-9天和13-15天后，ZnA组和ZnM组的鱼油摄入量分别增加，在自选期结束时，ZnM组和ZnA组大鼠分别消耗约2.0克/天和4.5克/天的鱼油。在自选期间，ZnD组大鼠的鱼油摄入比例[鱼油摄入量（克）/总摄入量（克）]是三组中最低的，而ZnA组大鼠的该比例是最高的。总之，我们发现锌状态会改变鱼油和猪油的选择模式，且ZnD组大鼠对鱼油没有偏好。
