Weigand Edgar, Egenolf Jennifer
Institute of Nutritional Physiology and Animal Nutrition, Justus Liebig University, Heinrich-Buff-Ring 29-32, 35392 Giessen, Germany.
J Nutr Metab. 2017;2017:4798963. doi: 10.1155/2017/4798963. Epub 2017 Mar 29.
The aim of the study was to examine whether a moderate zinc deficiency alters hepatic lipid composition. Male weanling rats, assigned to five groups (8 animals each), were fed low-carbohydrate high-fat diets supplemented with 7 or 50 mg Zn/kg (LZ or HZ) and 22% cocoa butter (CB) or 22% safflower oil (SF) for four weeks. One group each had free access to the LZ-CB and LZ-SF diets, one group each was restrictedly fed the HZ-CB and HZ-SF diets in matching amounts, and one group had free access to the HZ-SF diet (ad libitum control). The rats fed the LZ diets had significantly lower energy intakes and final body weights than the ad libitum control group, and lower plasma and femur Zn concentrations than the animals consuming the HZ diets. Hepatic cholesterol, triacylglycerol and phospholipid concentrations, and fatty acid composition of hepatic triacylglycerols and phospholipids did not significantly differ between the LZ and their respective HZ groups, but were greatly affected by dietary fat source. In conclusion, the moderate Zn deficiency did not significantly alter liver lipid concentrations and fatty acid composition.
本研究的目的是检验中度锌缺乏是否会改变肝脏脂质组成。将雄性断乳大鼠分为五组（每组8只），分别喂食补充了7或50毫克锌/千克（低锌或高锌）以及22%可可脂（CB）或22%红花油（SF）的低碳水化合物高脂肪饮食，持续四周。一组可自由摄取低锌 - 可可脂和低锌 - 红花油饮食，一组分别限量喂食等量的高锌 - 可可脂和高锌 - 红花油饮食，还有一组可自由摄取高锌 - 红花油饮食（随意进食对照组）。喂食低锌饮食的大鼠能量摄入量和最终体重显著低于随意进食对照组，血浆和股骨锌浓度也低于食用高锌饮食的动物。低锌组与其相应的高锌组之间，肝脏胆固醇、三酰甘油和磷脂浓度以及肝脏三酰甘油和磷脂的脂肪酸组成并无显著差异，但受饮食脂肪来源的影响很大。总之，中度锌缺乏并未显著改变肝脏脂质浓度和脂肪酸组成。
