Kazakov Dmitry V, Kacerovska Denisa, Hantschke Markus, Zelger Bernhard, Kutzner Heinz, Requena Luis, Grayson Wayne, Bisceglia Michele, Schaller Jörg, Kempf Werner, Denisjuk Natalia, Michal Michal
Sikl's Department of Pathology, Charles University Medical Faculty Hospital, Pilsen, Czech Republic.
Am J Dermatopathol. 2011 Aug;33(6):557-68. doi: 10.1097/DAD.0b013e318206c1a3.
Mixed tumor, eccrine type, is a rare cutaneous adnexal neoplasm, mostly reported as isolated case reports. A systematic analysis of its histopathologic and immunohistochemical features has not previously been performed on a large series. The purpose of our investigation was to study a large number of cutaneous eccrine mixed tumors so as to fully characterize the entire spectrum of changes in the epithelial and stromal components, with an emphasis on unusual histopathologic features that may represent a diagnostic pitfall. This article reports a light microscopic and immunohistochemical study of 50 cases of eccrine mixed tumor, complemented by a literature review. Our study identified some unusual histopathologic features, thus extending the morphologic spectrum of this neoplasm. These included prominent cribriform areas, clear cell change, pseudorosette structures, prominent osseous metaplasia, and physaliphorous-like cells. Most of these features have not been previously recorded in eccrine mixed tumors and may represent a potential diagnostic pitfall.
小汗腺型混合瘤是一种罕见的皮肤附属器肿瘤，大多以个案报道形式呈现。此前尚未对大量病例进行过其组织病理学和免疫组化特征的系统分析。我们研究的目的是对大量皮肤小汗腺混合瘤进行研究，以全面描述上皮和间质成分的各种变化，重点关注可能构成诊断陷阱的不寻常组织病理学特征。本文报告了50例小汗腺混合瘤的光镜和免疫组化研究，并辅以文献综述。我们的研究发现了一些不寻常的组织病理学特征，从而扩展了该肿瘤的形态学谱。这些特征包括显著的筛状区域、透明细胞改变、假菊形团结构、显著的骨化生以及类泡状细胞。这些特征大多此前未在小汗腺混合瘤中记录，可能构成潜在的诊断陷阱。
