Molecular Mutagenesis & DNA Repair Unit, Istituto Nazionale Ricerca Cancro, Genova, Italy.
Mini Rev Med Chem. 2011 Jun;11(7):591-8. doi: 10.2174/138955711795906897.
High grade gliomas can be seldom controlled, due to the infiltrative nature of these tumors and the presence of cell populations resistant to radio- and chemotherapy. Current research aims to develop novel therapeutic approaches to track and eliminate the disseminated glioma-driving cells. Selected delivery of therapeutic agents taking advantage of the tropism of normal stem cells for glioma cells might be one.
高级别胶质瘤很少能得到控制，这是由于这些肿瘤的浸润性和存在对放化疗有抵抗性的细胞群体。目前的研究旨在开发新的治疗方法来追踪和消除播散的胶质瘤驱动细胞。利用正常干细胞对胶质瘤细胞的趋向性来选择输送治疗剂可能是一种方法。
