Xu Feng, Zhu Jian-Hong
Department of Neurosurgery, Shanghai Neurosurgical Center, Huashan Hospital of Fudan University, Shanghai 200040, China.
Neurosci Bull. 2007 Nov;23(6):363-9. doi: 10.1007/s12264-007-0054-6.
Various studies have demonstrated the tremendous tropism of stem cells for malignant gliomas, making these cells a potential vehicle for delivery of therapeutic genes to disseminated glioma cells. However, little is known about the mechanisms underlying the glioma-induced tropism of stem cells. Soluble factors including chemokines or growth factors released and expressed by glioma cells at least mediate the tropism of stem cells for gliomas. Here we review the possible mechanisms of stem cells tropism for malignant gliomas.
多项研究已证明干细胞对恶性胶质瘤具有巨大的趋向性，使这些细胞成为向播散性胶质瘤细胞递送治疗性基因的潜在载体。然而，关于胶质瘤诱导的干细胞趋向性的潜在机制知之甚少。胶质瘤细胞释放和表达的包括趋化因子或生长因子在内的可溶性因子至少介导了干细胞对胶质瘤的趋向性。在此，我们综述干细胞对恶性胶质瘤趋向性的可能机制。
