Department of Genetics and Development, Columbia University, New York, New York, USA.
Gastroenterology. 2011 Aug;141(2):439-42. doi: 10.1053/j.gastro.2011.06.011. Epub 2011 Jun 17.
One of the least anticipated and less heralded outcomes of mouse genetics has been to rediscover whole organism physiology. Among the many unexpected findings that it has brought to our attention has been the realization that gut-derived serotonin is a hormone-inhibiting bone formation. The importance of this discovery presented in this review is 2-fold. First, it provides a molecular explanation for 2 human genetic diseases-osteoporosis, pseudoglioma, and high bone mass syndrome; second, it suggests a novel and anabolic way to treat osteoporosis. These findings illustrate the importance of the gastrointestinal tract in the regulation of organ physiology at yet another extraluminal site.
老鼠遗传学最出人意料和鲜为人知的结果之一是重新发现了整个生物体生理学。它引起了我们的注意，其中许多意想不到的发现之一是，肠道衍生的血清素是一种抑制骨形成的激素。本文综述的重要性有两个方面。首先，它为两种人类遗传疾病——骨质疏松症、假神经胶质瘤和高骨量综合征提供了分子解释；其次，它提示了一种治疗骨质疏松症的新的合成代谢方法。这些发现说明了胃肠道在调节另一个腔外器官生理学中的重要性。
