AP-HP, University Paris-East, Department of Psychiatry, Henri Mondor-Albert Chenevier Hospitals, Créteil, F-94010, France.
J Affect Disord. 2011 Dec;135(1-3):377-9. doi: 10.1016/j.jad.2011.06.001. Epub 2011 Jun 22.
Circadian rhythm instability and abnormalities of melatonin secretion are considered as trait markers of bipolar disorder. Melatonin is secreted by the pineal gland. We investigated pineal volume in patients with bipolar disorder, and expected to observe smaller than normal pineal glands in cases of bipolar disorder.
The primary outcome was the total pineal volume measured for each pineal gland with T1 MRI sequence. Twenty patients with bipolar I and II disorder and twenty controls were recruited. Pineal glands with large cysts (type 3) were excluded.
After exclusion of individuals with type 3 cysts, 32 subjects were analyzed for total pineal volume (16 patients with bipolar disorder and 16 controls). Total pineal volume did not differ significantly between patients (total pineal volume=115+/-54.3mm(3)) and controls (total pineal volume=110+/-40.5mm(3)).
Contrary to our hypothesis, no difference in total pineal volume between patients with bipolar disorder and healthy subjects was observed. These results indicate that the putative dysfunction of the pineal gland in bipolar disorder could be not directly related to an abnormal volume of the pineal gland.
昼夜节律不稳定和褪黑素分泌异常被认为是双相情感障碍的特征性标志物。褪黑素由松果体分泌。我们研究了双相情感障碍患者的松果体体积，预计会观察到双相情感障碍患者的松果体体积小于正常。
主要结局是用 T1 MRI 序列测量每个松果体的松果体总容积。招募了 20 名双相 I 型和 II 型障碍患者和 20 名对照者。排除有 3 型囊肿（类型 3）的个体。
排除 3 型囊肿个体后，对 32 名受试者的松果体总容积（16 名双相障碍患者和 16 名对照者）进行了分析。患者（松果体总容积=115+/-54.3mm(3)）和对照组（松果体总容积=110+/-40.5mm(3)）之间的松果体总容积无显著差异。
与我们的假设相反，未观察到双相情感障碍患者和健康受试者之间松果体总容积存在差异。这些结果表明，双相情感障碍中假定的松果体功能障碍可能与松果体体积异常无关。
