健康志愿者的松果体体积与昼夜褪黑素水平：一种跨学科研究方法。

Pineal volume and circadian melatonin profile in healthy volunteers: an interdisciplinary approach.

作者信息

Nölte Ingo, Lütkhoff Ann-Theres, Stuck Boris A, Lemmer Björn, Schredl Michael, Findeisen Peter, Groden Christoph

机构信息

Department of Neuroradiology, Medical Faculty Mannheim of the University of Heidelberg, Germany.

出版信息

J Magn Reson Imaging. 2009 Sep;30(3):499-505. doi: 10.1002/jmri.21872.

DOI:10.1002/jmri.21872

PMID:19630077

Abstract

PURPOSE

To correlate pineal parenchyma volume (PP) to circadian melatonin profiles and to determine the 24-hour melatonin per volume of pineal tissue (MLPV). Furthermore, we compared melatonin profiles of cystic and solid glands.

METHODS

In 15 healthy male subjects (20-27 years) the PP was determined using high-resolution magnetic resonance imaging (trueFISP, isotropic voxel: 0.8 mm(3)). Melatonin plasma concentrations (MC) were determined every 2 hours for 24 hours.

RESULTS

Mean PP was 125 +/- 54 mm(3). PP correlated linearly to maximum MC and to 24-hour melatonin (r = 0.61 and r = 0.64, P < 0.05) but not to minimum MC. The 24-hour melatonin was 653 +/- 242.6 pg/mL, MLPV was 5.8 +/- 2.3 pg/mL*ml(-1). Nine pineal glands were solid and six were cystic. PP of solid glands showed higher linear correlations to maximum melatonin, to 24-hour melatonin, and to the slope of the melatonin increase of the curve (P < 0.05).

CONCLUSION

PP correlates linearly to melatonin plasma concentrations in humans. MLPV displays similar interindividual differences as 24-hour melatonin. PP of solid glands show better correlation to melatonin profiles than cystic.

摘要

目的

将松果体实质体积（PP）与昼夜褪黑素水平相关联，并确定每单位松果体组织体积的24小时褪黑素含量（MLPV）。此外，我们比较了囊性和实性松果体的褪黑素水平。

方法

对15名健康男性受试者（20 - 27岁）使用高分辨率磁共振成像（trueFISP，各向同性体素：0.8 mm³）测定PP。每2小时测定一次褪黑素血浆浓度（MC），共24小时。

结果

平均PP为125±54 mm³。PP与最大MC以及24小时褪黑素呈线性相关（r = 0.61和r = 0.64，P < 0.05），但与最小MC无关。24小时褪黑素为653±242.6 pg/mL，MLPV为5.8±2.3 pg/mL·ml⁻¹。9个松果体为实性，6个为囊性。实性松果体的PP与最大褪黑素水平、24小时褪黑素水平以及褪黑素曲线上升斜率的线性相关性更高（P < 0.05）。