Center of Research on Psychology in Somatic Diseases (CoRPS), Department of Medical Psychology, Tilburg University, Tilburg, The Netherlands.
Respir Med. 2011 Sep;105(9):1388-95. doi: 10.1016/j.rmed.2011.05.004. Epub 2011 Jun 23.
The usefulness of any questionnaire in clinical management and research trials depends on its ability to indicate a likelihood of treatment success during follow-up. The Minimal Clinically Important Difference (MCID) reflects a clinically relevant change score. The aim of this study was to estimate the MCID for the Fatigue Assessment Scale (FAS) in patients with sarcoidosis.
Outpatients (n = 321) of the ild care team of the Department of Respiratory Medicine of the Maastricht University Medical Centre, The Netherlands, participated in this prospective follow-up study. Anchor-based and distribution-based methods were used to estimate the MCID. Based on the anchor Physical Quality of Life, a Receiver Operating Characteristic (ROC) was obtained. The distribution-based methods consisted of the Effect Size and Standard Error Measurement (SEM).
The anchor-based MCID found with ROC was 3.5. The distribution-based methods showed that the corresponding change scores in the FAS for a small effect was 4.2. The SEM criterion was 3.6 points change in the FAS.
Based on the anchor-based and distribution-based methods, the MCID is a 4-point difference on the FAS. This MCID can be used in the follow-up of fatigue (FAS) in clinical trials and in the management of individual sarcoidosis cases.
任何问卷在临床管理和研究试验中的有用性都取决于其在随访期间指示治疗成功可能性的能力。最小临床重要差异（MCID）反映了临床相关的变化分数。本研究旨在估计肌痛评估量表（FAS）在结节病患者中的 MCID。
荷兰马斯特里赫特大学医学中心呼吸医学部门的 ild 护理团队的 321 名门诊患者参加了这项前瞻性随访研究。使用基于锚点和基于分布的方法来估计 MCID。基于锚定物理生活质量，获得了接收器工作特征（ROC）。基于分布的方法包括效应大小和标准误差测量（SEM）。
ROC 得出的基于锚点的 MCID 为 3.5。基于分布的方法表明，FAS 的小效应的相应变化分数为 4.2。SEM 标准为 FAS 变化 3.6 分。
基于基于锚点和基于分布的方法，MCID 是 FAS 上的 4 分差异。该 MCID 可用于临床试验中疲劳（FAS）的随访以及个体结节病病例的管理。
