NADPH再生系统对离体大鼠肝细胞中联苯代谢的影响。
The effect of an NADPH-regenerating system on biphenyl metabolism in isolated rat hepatocytes.
作者信息
Jones R S, Mendis D, Parke D V
出版信息
Biochim Biophys Acta. 1977 Nov 7;500(1):124-31. doi: 10.1016/0304-4165(77)90052-6.
PMID:21701
Abstract
Biphenyl 4-hydroxylation was studied in isolated rat hepatocytes. It was found that there was in inter-relationship between 4-hydroxylase activity and glucuronidase activity, removal of 4-hydroxybiphenyl by conjugation being necessary to stimulate a second phase of hydroxylation. Addition of an NADPH-regenerating system resulted in an initial depression of both processes, but later their activities were enhanced. This action could not be explained by the presence of non-viable cells.
摘要
在分离的大鼠肝细胞中研究了联苯4-羟基化作用。发现4-羟化酶活性与葡萄糖醛酸酶活性之间存在相互关系，通过结合作用去除4-羟基联苯对于刺激第二阶段的羟基化作用是必要的。添加NADPH再生系统导致这两个过程最初受到抑制，但随后它们的活性增强。这种作用不能用存在无活力的细胞来解释。
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