不同物种肝脏制剂体外对联苯羟化作用的荧光研究。
A fluorimetric study of the hydroxylation of biphenyl in vitro by liver preparations of various species.
作者信息
Creaven P J, Parke D V, Williams R T
出版信息
Biochem J. 1965 Sep;96(3):879-85. doi: 10.1042/bj0960879.
Abstract
- A study has been made of the enzymic hydroxylation of biphenyl by liver microsomal preparations from 11 species of animals, by using a fluorescence method for the micro-estimation of the hydroxylation products, 2- and 4-hydroxybiphenyl. 2. Livers from all species examined produced 4-hydroxybiphenyl, but only those from mice, hamsters, cats, coypus and frogs produced 2-hydroxybiphenyl as well. 3. Adult rat and rabbit livers produced only the 4-isomer, but livers from the young of these species also produced the 2-isomer. 4. The properties and requirements of the 4-hydroxylating enzyme of rabbit liver were studied. 5. The results are discussed and it is suggested that the 2- and 4-hydroxylating enzymes are different.
摘要
- 采用荧光法对11种动物肝脏微粒体制剂中联苯的酶促羟基化反应进行了研究，以微量测定羟基化产物2-羟基联苯和4-羟基联苯。2. 所有受试物种的肝脏都产生了4-羟基联苯，但只有小鼠、仓鼠、猫、河狸和青蛙的肝脏同时还产生了2-羟基联苯。3. 成年大鼠和兔子的肝脏只产生4-异构体，但这些物种幼体的肝脏也产生2-异构体。4. 对兔肝4-羟化酶的性质和需求进行了研究。5. 对结果进行了讨论，并提出2-羟化酶和4-羟化酶是不同的。
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本文引用的文献
1
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Arch Biochem Biophys. 1956 Apr;61(2):431-41. doi: 10.1016/0003-9861(56)90366-6.
2
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3
A spectrofluorimetric study of the 7-hydroxylation of coumarin by liver microsomes.肝脏微粒体对香豆素7-羟基化作用的荧光分光光度研究。
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