不同物种肝脏制剂体外对联苯羟化作用的荧光研究。
A fluorimetric study of the hydroxylation of biphenyl in vitro by liver preparations of various species.
作者信息
Creaven P J, Parke D V, Williams R T
出版信息
Biochem J. 1965 Sep;96(3):879-85. doi: 10.1042/bj0960879.
Abstract
- A study has been made of the enzymic hydroxylation of biphenyl by liver microsomal preparations from 11 species of animals, by using a fluorescence method for the micro-estimation of the hydroxylation products, 2- and 4-hydroxybiphenyl. 2. Livers from all species examined produced 4-hydroxybiphenyl, but only those from mice, hamsters, cats, coypus and frogs produced 2-hydroxybiphenyl as well. 3. Adult rat and rabbit livers produced only the 4-isomer, but livers from the young of these species also produced the 2-isomer. 4. The properties and requirements of the 4-hydroxylating enzyme of rabbit liver were studied. 5. The results are discussed and it is suggested that the 2- and 4-hydroxylating enzymes are different.
摘要
- 采用荧光法对11种动物肝脏微粒体制剂中联苯的酶促羟基化反应进行了研究，以微量测定羟基化产物2-羟基联苯和4-羟基联苯。2. 所有受试物种的肝脏都产生了4-羟基联苯，但只有小鼠、仓鼠、猫、河狸和青蛙的肝脏同时还产生了2-羟基联苯。3. 成年大鼠和兔子的肝脏只产生4-异构体，但这些物种幼体的肝脏也产生2-异构体。4. 对兔肝4-羟化酶的性质和需求进行了研究。5. 对结果进行了讨论，并提出2-羟化酶和4-羟化酶是不同的。
相似文献
1
A fluorimetric study of the hydroxylation of biphenyl in vitro by liver preparations of various species.不同物种肝脏制剂体外对联苯羟化作用的荧光研究。
Biochem J. 1965 Sep;96(3):879-85. doi: 10.1042/bj0960879.
2
A spectrofluorimetric study of the 7-hydroxylation of coumarin by liver microsomes.肝脏微粒体对香豆素7-羟基化作用的荧光分光光度研究。
Biochem J. 1965 Aug;96(2):390-8. doi: 10.1042/bj0960390.
3
Anthranilic acid hydroxylation by rabbit-liver microsomes.兔肝微粒体对邻氨基苯甲酸的羟基化作用。
Biochim Biophys Acta. 1966 Feb 14;113(2):244-54. doi: 10.1016/s0926-6593(66)80065-6.
4
5
Microsomal biphenyl hydroxylation: the formation of 3- hydroxybiphenyl and biphenyl catechol.
Mol Pharmacol. 1978 Jan;14(1):145-54.
6
[Studies on microsomal hydroxylation of naphthalene].[萘的微粒体羟基化研究]
Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1969;262(3):375-87.
7
[Comparative studies in vivo and in vitro on the formation of phenolic biphenyl metabolites in various animal species (author's transl)[].
Arzneimittelforschung. 1976;26(12):2178-82.
8
In vitro enhancement of hepatic microsomal biphenyl 2-hydroxylation by carcinogens.致癌物对肝微粒体联苯2-羟化作用的体外增强
Nature. 1974 Dec 6;252(5483):488-9. doi: 10.1038/252488a0.
9
Biphenyl hydroxylations and spectrally apparent interactions with liver microsomes from hamsters pre-treated with phenobarbitone and 3-methylcholanthrene.
Xenobiotica. 1975 Jun;5(6):357-76. doi: 10.3109/00498257509056106.
10
The biochemistry of aromatic amines. 10. Enzymic N-hydroxylation of arylamines and conversion of arylhydroxylamines into o-aminophenols.芳香胺的生物化学。10. 芳胺的酶促N-羟基化及芳基羟胺向邻氨基苯酚的转化。
Biochem J. 1964 May;91(2):362-9. doi: 10.1042/bj0910362.
引用本文的文献
1
Structure-Function Studies of Naphthalene, Phenanthrene, Biphenyl, and Their Derivatives in Interaction with and Oxidation by Cytochromes P450 2A13 and 2A6.萘、菲、联苯及其衍生物与细胞色素P450 2A13和2A6相互作用及被其氧化的结构-功能研究
Chem Res Toxicol. 2016 Jun 20;29(6):1029-40. doi: 10.1021/acs.chemrestox.6b00083. Epub 2016 May 12.
2
The effects of carbon disulphide on rat liver microsomal mixed-function oxidases, in vivo and in vitro.二硫化碳对大鼠肝脏微粒体混合功能氧化酶的体内及体外作用。
Biochem J. 1980 Apr 15;188(1):107-12. doi: 10.1042/bj1880107.
3
Relationship between biotransformation and the toxicity and fate of xenobiotic chemicals in fish.鱼类体内生物转化与外源化学物质的毒性及归宿之间的关系。
Environ Health Perspect. 1980 Feb;34:115-31. doi: 10.1289/ehp.8034115.
4
Uptake, metabolism, and elimination of diphenyl ether by trout and stickleback.
Bull Environ Contam Toxicol. 1981 Feb;26(2):243-7. doi: 10.1007/BF01622084.
5
Activity and inducibility of aryl hydrocarbon hydroxylase in the eelpout Zoarces viviparus (L.).绵鳚（Zoarces viviparus (L.)）中芳烃羟化酶的活性与诱导性。
Arch Environ Contam Toxicol. 1983 Nov;12(6):673-8. doi: 10.1007/BF01060750.
6
Species differences in pharmacokinetics.药代动力学的种属差异。
Vet Res Commun. 1983 Dec;7(1-4):285-300. doi: 10.1007/BF02228636.
7
Determination of cytochrome P-448 activity in biological tissues.生物组织中细胞色素P-448活性的测定。
Biochem J. 1984 Jul 1;221(1):81-8. doi: 10.1042/bj2210081.
8
The fluorescence of some biphenyl derivatives.一些联苯衍生物的荧光
Biochem J. 1965 Sep;96(3):872-8. doi: 10.1042/bj0960872.
9
The effects of some terpenoids and other dietary anutrients on hepatic drug-metabolizing enzymes.某些萜类化合物和其他膳食营养成分对肝脏药物代谢酶的影响。
Biochem J. 1969 Jun;113(2):12P. doi: 10.1042/bj1130012pa.
10
Metabolic hydroxylations of trans-stilbene.反式芪的代谢羟基化作用。
Biochem J. 1969 Jan;111(1):35-41. doi: 10.1042/bj1110035.
本文引用的文献
1
Enzymatic hydroxylation of aromatic compounds.芳香族化合物的酶促羟基化作用。
Arch Biochem Biophys. 1956 Apr;61(2):431-41. doi: 10.1016/0003-9861(56)90366-6.
2
The fluorescence of some biphenyl derivatives.一些联苯衍生物的荧光
Biochem J. 1965 Sep;96(3):872-8. doi: 10.1042/bj0960872.
3
A spectrofluorimetric study of the 7-hydroxylation of coumarin by liver microsomes.肝脏微粒体对香豆素7-羟基化作用的荧光分光光度研究。
Biochem J. 1965 Aug;96(2):390-8. doi: 10.1042/bj0960390.
Zotero 插件