Department of Pathology, Christchurch School of Medicine and Health Sciences, University of Otago, PO Box 4345, Christchurch, 8140, New Zealand.
J Breath Res. 2011 Dec;5(4):046002. doi: 10.1088/1752-7155/5/4/046002. Epub 2011 Jun 23.
2-Aminoacetophenone can be detected in the breath of Pseudomonas aeruginosa colonized cystic fibrosis patients; however, low levels were also detected in a small proportion of healthy subjects. It was hypothesized that food, beverages, cosmetics or medications could be a source of contamination of 2-aminoacetophenone in breath. To determine the potential confounding of these products on 2-aminoacetophenone breath analysis, screening for this volatile was performed in the laboratory by gas chromatography/mass spectrometry and a food challenge study carried out. 2-Aminoacetophenone was detected in four of the 78 samples tested in vitro: corn chips and canned tuna (high pmol mol(-1)) and egg white and one of the three beers (low pmol mol(-1)). No 2-aminoacetophenone was detected in the CF medication or cosmetics tested. Twenty-eight out of 30 environmental air samples were negative for 2-aminoacetophenone (below 50 pmol mol(-1)). A challenge study with ten healthy subjects was performed to determine if 2-aminoacetophenone from corn chips was detectable on the breath after consumption. Analysis of mixed breath samples reported that the levels of 2-aminoacetophenone were immediately elevated after corn chip consumption, but after 2 h the level of 2-aminoacetophenone had reduced back to the 'baseline' for each subject.
2-氨基苯乙酮可以在定植于囊性纤维化患者肺部的铜绿假单胞菌的呼吸中被检测到；然而，在一小部分健康受试者中也检测到了低水平的 2-氨基苯乙酮。据推测，食物、饮料、化妆品或药物可能是呼吸中 2-氨基苯乙酮污染的来源。为了确定这些产品对 2-氨基苯乙酮呼吸分析的潜在干扰，通过气相色谱/质谱法在实验室中对这种挥发性物质进行了筛选，并进行了食物挑战研究。在体外测试的 78 个样本中，有四个样本检测到 2-氨基苯乙酮：玉米片和金枪鱼罐头（高 pmol/mol）和蛋清以及三种啤酒中的一种（低 pmol/mol）。在测试的 CF 药物或化妆品中未检测到 2-氨基苯乙酮。30 个环境空气样本中有 28 个（低于 50 pmol/mol）未检出 2-氨基苯乙酮。对 10 名健康受试者进行了一项挑战研究，以确定食用玉米片后是否能在呼吸中检测到玉米片中的 2-氨基苯乙酮。混合呼吸样本的分析表明，在食用玉米片后，2-氨基苯乙酮的水平立即升高，但 2 小时后，2-氨基苯乙酮的水平已回落到每个受试者的“基线”。
