Department of Gynecology, Charité University Medicine, Berlin, Germany.
Int J Gynecol Cancer. 2011 Nov;21(8):1458-64. doi: 10.1097/IGC.0b013e3182216aa7.
The aim of the study was to prove the surgical and oncological safety of radical vaginal trachelectomy (RVT) and laparoscopic lymphadenectomy for patients with early-stage cervical cancer who are seeking parenthood.
A database of 225 patients with early-stage cervical cancer and intention to treat by RVT after laparoscopic lymphadenectomy was prospectively maintained. A total of 212 patients were treated according to the protocol. The procedure was preformed in a standardized manner, and life table analysis was applied.
In the cohort of patients treated according to protocol, 8 recurrences occurred and 4 patients died from recurrence. The median follow-up time was 37 months (range, 0-171 months). The 5-year recurrence-free and overall survival was 94.4% and 97.4%, respectively. Perioperative and short-term postoperative complications were rare (2.8% and 7.5%, respectively). No severe long-term complications occurred.
Radical vaginal trachelectomy combined with laparoscopic lymphadenectomy is a safe method for treatment of patients with early-stage cervical cancer who are seeking parenthood.
本研究旨在证明对于有生育要求的早期宫颈癌患者，行根治性阴道子宫颈切除术（RVT）联合腹腔镜淋巴结切除术的手术和肿瘤学安全性。
前瞻性地维护了一个数据库，其中包含 225 例早期宫颈癌患者，且均计划接受腹腔镜淋巴结切除术后的 RVT 治疗。共有 212 例患者按照方案进行了治疗。该手术采用标准化方式进行，并应用生存表分析。
在按方案治疗的患者队列中，有 8 例复发，4 例患者死于复发。中位随访时间为 37 个月（范围：0-171 个月）。5 年无复发生存率和总生存率分别为 94.4%和 97.4%。围手术期和短期术后并发症罕见（分别为 2.8%和 7.5%）。未发生严重的长期并发症。
根治性阴道子宫颈切除术联合腹腔镜淋巴结切除术是治疗有生育要求的早期宫颈癌患者的一种安全方法。
