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噻吗洛尔与多佐胺联合治疗青光眼和高眼压症的疗效、安全性及耐受性

Efficacy, safety and tolerability of combination therapy with timolol and dorzolamide in glaucoma and ocular hypertension.

作者信息

Ichhpujani Parul, Katz L Jay

机构信息

William and Anna Goldberg Glaucoma Service.

出版信息

Drug Healthc Patient Saf. 2010;2:73-83. doi: 10.2147/dhps.s9757. Epub 2010 May 24.

DOI:10.2147/dhps.s9757
PMID:21701619
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3108696/
Abstract

Combination pharmacotherapy has simplified and improved glaucoma medication regimens. This update focuses on the previous and recent studies on efficacy and tolerability profile of dorzolamide-timolol in adult ocular hypertension and open angle glaucoma patients. Dorzolamide-timolol has been shown to be efficacious and well tolerated in clinical trials and the adverse effects reflect those of the individual components.

摘要

联合药物治疗简化并改善了青光眼药物治疗方案。本更新重点关注多佐胺-噻吗洛尔在成人高眼压症和开角型青光眼患者中的疗效和耐受性的既往及最新研究。在临床试验中，多佐胺-噻吗洛尔已被证明有效且耐受性良好，其不良反应反映了各成分的不良反应。

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1
Efficacy, safety and tolerability of combination therapy with timolol and dorzolamide in glaucoma and ocular hypertension.噻吗洛尔与多佐胺联合治疗青光眼和高眼压症的疗效、安全性及耐受性
Drug Healthc Patient Saf. 2010;2:73-83. doi: 10.2147/dhps.s9757. Epub 2010 May 24.
2
Topical dorzolamide 2%/timolol 0.5%: a review of its use in the treatment of open-angle glaucoma.局部用2%多佐胺/0.5%噻吗洛尔：其用于治疗开角型青光眼的综述
Drugs Aging. 2000 Dec;17(6):477-96. doi: 10.2165/00002512-200017060-00005.
3
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4
Rational use of the fixed combination of dorzolamide - timolol in the management of raised intraocular pressure and glaucoma.多佐胺-噻吗洛尔固定复方制剂在高眼压症和青光眼治疗中的合理应用。
Clin Ophthalmol. 2008 Jun;2(2):389-99. doi: 10.2147/opth.s1813.
5
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引用本文的文献

1
Safety, tolerability, and efficacy of fixed combination therapy with dorzolamide hydrochloride 2% and timolol maleate 0.5% in glaucoma and ocular hypertension.2%盐酸多佐胺与0.5%马来酸噻吗洛尔固定复方疗法治疗青光眼和高眼压症的安全性、耐受性及疗效
Clin Ophthalmol. 2010 Nov 22;4:1331-46. doi: 10.2147/OPTH.S14054.

本文引用的文献

1
Efficacy and safety of travoprost/timolol vs dorzolamide/timolol in patients with open-angle glaucoma or ocular hypertension.曲伏前列素/噻吗洛尔与多佐胺/噻吗洛尔治疗开角型青光眼或高眼压症患者的疗效与安全性比较
Clin Ophthalmol. 2009;3:629-36. doi: 10.2147/opth.s8011. Epub 2009 Nov 16.
2
Glaucoma medication persistence with a fixed combination versus multiple bottles.青光眼药物使用固定复方制剂与多瓶制剂的持续性比较
Curr Med Res Opin. 2009 Oct;25(10):2543-7. doi: 10.1185/03007990903260129.
3
Additive intraocular pressure reduction effect of fixed combination of maleate timolol 0.5%/dorzolamide 2% (Cosopt) on monotherapy with latanoprost (Xalatan) in patients with elevated intraocular pressure: a prospective, 4-week, open-label, randomized, controlled clinical trial.马来酸噻吗洛尔 0.5%/多佐胺 2%（适利达）固定组合制剂对升高的眼压患者单药治疗的降眼压附加作用：一项前瞻性、4 周、开放标签、随机、对照临床试验。
J Glaucoma. 2010 Jun-Jul;19(5):331-5. doi: 10.1097/IJG.0b013e3181b4cab4.
4
A patient preference comparison of Azarga (brinzolamide/timolol fixed combination) vs Cosopt (dorzolamide/timolol fixed combination) in patients with open-angle glaucoma or ocular hypertension.阿扎尔加（布林佐胺/噻吗洛尔固定组合）与可速必妥（多佐胺/噻吗洛尔固定组合）用于开角型青光眼或高眼压症患者的患者偏好比较
Clin Ophthalmol. 2008 Sep;2(3):623-8. doi: 10.2147/opth.s4088.
5
Rational use of the fixed combination of dorzolamide - timolol in the management of raised intraocular pressure and glaucoma.多佐胺-噻吗洛尔固定复方制剂在高眼压症和青光眼治疗中的合理应用。
Clin Ophthalmol. 2008 Jun;2(2):389-99. doi: 10.2147/opth.s1813.
6
Three-month, randomized, parallel-group comparison of brimonidine-timolol versus dorzolamide-timolol fixed-combination therapy.溴莫尼定-噻吗洛尔与多佐胺-噻吗洛尔固定复方疗法的三个月随机平行组比较
Curr Med Res Opin. 2009 Jul;25(7):1645-53. doi: 10.1185/03007990902994041.
7
The safety and efficacy of brinzolamide 1%/timolol 0.5% fixed combination versus dorzolamide 2%/timolol 0.5% in patients with open-angle glaucoma or ocular hypertension.1%布林佐胺/0.5%噻吗洛尔固定复方制剂与2%多佐胺/0.5%噻吗洛尔治疗开角型青光眼或高眼压症患者的安全性和有效性比较
J Glaucoma. 2009 Apr-May;18(4):293-300. doi: 10.1097/IJG.0b013e31818fb434.
8
Literature review and meta-analysis of topical carbonic anhydrase inhibitors and ocular blood flow.局部碳酸酐酶抑制剂与眼血流的文献综述及荟萃分析
Surv Ophthalmol. 2009 Jan-Feb;54(1):33-46. doi: 10.1016/j.survophthal.2008.06.002.
9
Dorzolamide/timolol fixed combination versus latanoprost/timolol fixed combination in patients with primary open-angle glaucoma or ocular hypertension.多佐胺/噻吗洛尔固定复方制剂与拉坦前列素/噻吗洛尔固定复方制剂治疗原发性开角型青光眼或高眼压症患者的疗效比较
Curr Eye Res. 2008 Feb;33(2):163-8. doi: 10.1080/02713680701832480.
10
The effects of dorzolamide 2% and dorzolamide/timolol fixed combination on retinal and optic nerve head blood flow in primary open-angle glaucoma patients.2%多佐胺及多佐胺/噻吗洛尔固定复方制剂对原发性开角型青光眼患者视网膜及视神经乳头血流的影响
Eye (Lond). 2008 Sep;22(9):1172-9. doi: 10.1038/sj.eye.6703071. Epub 2008 Jan 18.