多佐胺/噻吗洛尔固定复方制剂与拉坦前列素/噻吗洛尔固定复方制剂治疗原发性开角型青光眼或高眼压症患者的疗效比较
Dorzolamide/timolol fixed combination versus latanoprost/timolol fixed combination in patients with primary open-angle glaucoma or ocular hypertension.
作者信息
Cvenkel Barbara, Stewart Jeanette A, Nelson Lindsay A, Stewart William C
机构信息
University Eye Clinic Ljubljana, Ljubljana, Slovenia.
出版信息
Curr Eye Res. 2008 Feb;33(2):163-8. doi: 10.1080/02713680701832480.
PURPOSE
The efficacy of dorzolamide/timolol fixed combination (DTFC) versus latanoprost/timolol fixed combination (LTFC) in open-angle glaucoma or ocular hypertensive patients.
METHODS
Patients were randomized to DTFC or LTFC for 6 weeks and switched to opposite treatment for Period 2.
RESULTS
Thirty-two completed patients had a mean diurnal IOP of 19.5+/-3.2 mmHg for DTFC and 18.9+/-3.4 mmHg for LTFC (p=0.12), with no significant difference found between DTFC and LTFC at any timepoint following a Bonferroni correction (p>or=0.01).
CONCLUSIONS
Patients treated with DTFC and LTFC have a statistically similar ocular hypotensive effect.
目的
比较多佐胺/噻吗洛尔固定复方制剂（DTFC）与拉坦前列素/噻吗洛尔固定复方制剂（LTFC）治疗开角型青光眼或高眼压症患者的疗效。
方法
患者被随机分为DTFC组或LTFC组，治疗6周，然后在第二阶段改用相反的治疗方案。
结果
32例完成研究的患者中，DTFC组的平均日间眼压为19.5±3.2 mmHg，LTFC组为18.9±3.4 mmHg（p = 0.12），经Bonferroni校正后，在任何时间点DTFC与LTFC之间均未发现显著差异（p≥0.01）。
结论
接受DTFC和LTFC治疗的患者在眼压降低效果上具有统计学意义的相似性。
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