Pozharov V P, Seredenko M M
Fiziol Zh SSSR Im I M Sechenova. 1990 May;76(5):678-84.
Anesthetized rats breathed during 1 hr with gas mixtures containing 16 to 6 per cent of oxygen. At 6 per cent of oxygen, the hypoxia of pulmonary tissue and its processes of peroxide oxidation of lipids entails a sharp increase in elastic resistance against breathing. This is combined with insignificant disorders in tidal volume which is not compensated by an increase in the breathing rate. General mechanisms of external respiration disorders in various types of hypoxia and in stress, were revealed.
麻醉后的大鼠用含氧量为16%至6%的混合气体呼吸1小时。当氧气含量为6%时，肺组织的缺氧及其脂质过氧化过程会导致呼吸弹性阻力急剧增加。这伴随着潮气量的轻微紊乱，而潮气量的紊乱并未因呼吸频率的增加而得到补偿。揭示了各种类型缺氧和应激状态下外呼吸障碍的一般机制。
