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[脂质体抗缺氧作用的生理机制]

[The physiological mechanisms of the antihypoxic action of the liposomes].

作者信息

Pozharov V P, Miniaĭlenko T D, Stefanov A V, Bryginskiĭ S A, Seredenko M M, Lishko V K

出版信息

Fiziol Zh SSSR Im I M Sechenova. 1990 Jul;76(7):897-902.

PMID:2174384
Abstract

The effect of phospholipids introduced into the vascular bed in the form of liposomes, was studied in pats in conditions of breathing with hypoxic gas mixture containing 7% of oxygen in nitrogen. The liposomes were shown to improve the oxygen diffusion from the blood into tissues and from air to the blood. In the result of this, the degree of the tissue hypoxia is considerably reduced, the process of peroxide oxidation of lipids is inhibited, and the efficacy of external respiration and gas exchange is increased.

摘要

以脂质体形式引入血管床的磷脂的作用,是在吸入含7%氧气的氮气的低氧混合气体的条件下,在实验对象身上进行研究的。结果表明,脂质体可改善氧气从血液向组织以及从空气向血液的扩散。由此,组织缺氧程度显著降低,脂质过氧化过程受到抑制,外呼吸和气体交换效率提高。

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