Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan.
Int J Cancer. 2012 Jun 1;130(11):2629-37. doi: 10.1002/ijc.26249. Epub 2011 Nov 19.
The incidence of breast and genital tract cancers is increasing among Taiwanese women, but the age specificity and histopathological features of these cancers have not been determined. We used a descriptive epidemiological method and data from the Taiwan Cancer Registry (1979-2007) to examine secular trends in the age-specific incidences of female breast cancer, three major female genital tract cancers and the histopathological subtypes of these cancers. Age-specific incidence rates in the United States (1978-2002) were used as an external reference, and the incidence rates of all malignancies and of malignant brain tumors were used as internal references. We found that age-adjusted incidence rates of female breast, uterine, and ovarian cancers increased in Taiwan from 1979 to 2007, whereas the incidence of cervical cancer decreased after 1998. The largest increase was observed for ductal and lobular carcinomas of the breast and endometrioid carcinomas of the uterus and ovary in women ≤55 years, all of these tumors show a high prevalence of hormone receptor expressions. In addition, hormone-receptor-positive rates of breast cancer were uniquely higher in younger, as opposed to older, Taiwanese women. These findings indicate that estrogen-related cancers rapidly emerge in young women in Taiwan and that incidence rates are catching up with that of women living in the United States.
台湾地区女性的乳腺癌和女性生殖系统癌症发病率正在上升，但这些癌症的年龄特异性和组织病理学特征尚未确定。我们采用描述性流行病学方法和台湾癌症登记处（1979-2007 年）的数据，研究了女性乳腺癌、三种主要女性生殖系统癌症以及这些癌症的组织病理学亚型的年龄特异性发病率的时间变化趋势。以美国（1978-2002 年）的年龄标准化发病率作为外部参照，所有恶性肿瘤和恶性脑肿瘤的发病率作为内部参照。结果发现，1979 年至 2007 年，台湾地区女性乳腺癌、子宫癌和卵巢癌的年龄标准化发病率呈上升趋势，而宫颈癌的发病率在 1998 年后则下降。55 岁以下女性的乳腺癌、子宫和卵巢的导管癌和小叶癌以及子宫内膜癌发病率增幅最大，这些肿瘤均显示出较高的激素受体表达。此外，台湾年轻女性的乳腺癌激素受体阳性率明显高于老年女性。这些发现表明，与美国女性相比，台湾地区年轻女性的雌激素相关癌症发病率迅速上升，且发病率正在迎头赶上。
