两种新型变菌素的抗菌活性比较
Comparative antimicrobial activity of two new mutacins.
作者信息
Nicolas G G, LaPointe G, Lavoie M C
机构信息
Département de Biochimie, Microbiologie et Bio-informatique, Faculté des Sciences et Génie, Université Laval, Québec, Canada.
出版信息
West Indian Med J. 2010 Dec;59(6):602-6.
OBJECTIVES
To compare the in vitro activity of mutacins D-123.1 and F-59.1 against different bacteria including antibiotic-resistant strains, in order to evaluate their application potential.
DESIGN AND METHODS
The antibacterial activity spectrum of purified F-59.1 and the MIC and MBC of F-59.1 and D-123.1 against target bacteria were determined.
RESULTS
Most bacteria were inhibited by the purified mutacins. Mutacin F-59.1 shows a relatively wide activity spectrum. Mutacin D-123.1 has low Minimum Inhibitory Concentrations [MICs] (0.25-4 microg/ml) against human pathogens while F-59.1 has higher MICs (3.2-12.8 microg/ml) mainly against food-borne pathogens.
CONCLUSION
The effectiveness of mutacins D-123.1 and F-59.1 against human and food-borne pathogens is demonstrated. Mutacin D-123.1 shows potential as a new antibiotic while F-59.1 shows promising application in food products.
目的
比较变菌素D - 123.1和F - 59.1对包括耐药菌株在内的不同细菌的体外活性，以评估它们的应用潜力。
设计与方法
测定纯化后的F - 59.1的抗菌活性谱以及F - 59.1和D - 123.1对目标细菌的最低抑菌浓度（MIC）和最低杀菌浓度（MBC）。
结果
大多数细菌受到纯化后的变菌素抑制。变菌素F - 59.1显示出相对较宽的活性谱。变菌素D - 123.1对人类病原体的最低抑菌浓度较低（0.25 - 4微克/毫升），而F - 59.1的最低抑菌浓度较高（3.2 - 12.8微克/毫升），主要针对食源性病原体。
结论
证实了变菌素D - 123.1和F - 59.1对人类和食源性病原体的有效性。变菌素D - 123.1显示出作为新型抗生素的潜力，而F - 59.1在食品中显示出有前景的应用。
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