变形链球菌 UA159 来源的变聚糖可有效对抗多种链球菌。
Mutacins from Streptococcus mutans UA159 are active against multiple streptococcal species.
机构信息
Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, Kansas 66160, USA.
出版信息
Appl Environ Microbiol. 2011 Apr;77(7):2428-34. doi: 10.1128/AEM.02320-10. Epub 2011 Feb 4.
Abstract
Streptococcus mutans UA159, whose genome is completely sequenced, produces two nonlantibiotic mutacins, mutacin IV (encoded by nlmAB) and mutacin V (encoded by nlmC). In this study, we investigated the contribution of nlmA and nlmB to mutacin IV activity and demonstrated by performing genetic studies as well as by using semipurified molecules that, in contrast to a previous report, both of these genes are required for optimum mutacin IV activity. We also showed that mutacin IV is active against multiple Streptococcus species. In contrast, mutacin V displayed a narrower inhibitory range than mutacin IV. Our results suggest that mutacin IV and mutacin V may act synergistically to inhibit various organisms.
摘要
变异链球菌 UA159 的基因组已完全测序，其产生两种非类菌素 mutacins，mutacin IV（由 nlmAB 编码）和 mutacin V（由 nlmC 编码）。在这项研究中，我们通过遗传研究以及使用半纯化分子研究了 nlmA 和 nlmB 对 mutacin IV 活性的贡献，并证明与之前的报道相反，这两个基因都是产生最佳 mutacin IV 活性所必需的。我们还表明 mutacin IV 对多种链球菌具有活性。相比之下，mutacin V 的抑制范围比 mutacin IV 窄。我们的结果表明 mutacin IV 和 mutacin V 可能协同作用以抑制各种生物体。
相似文献
1
Mutacins from Streptococcus mutans UA159 are active against multiple streptococcal species.变形链球菌 UA159 来源的变聚糖可有效对抗多种链球菌。
Appl Environ Microbiol. 2011 Apr;77(7):2428-34. doi: 10.1128/AEM.02320-10. Epub 2011 Feb 4.
2
The group I strain of Streptococcus mutans, UA140, produces both the lantibiotic mutacin I and a nonlantibiotic bacteriocin, mutacin IV.变形链球菌I群菌株UA140可产生羊毛硫抗生素变链菌素I和一种非羊毛硫抗生素细菌素——变链菌素IV。
Appl Environ Microbiol. 2001 Jan;67(1):15-21. doi: 10.1128/AEM.67.1.15-21.2001.
3
SMU.152 acts as an immunity protein for mutacin IV.SMU.152 作为 mutacin IV 的免疫蛋白。
J Bacteriol. 2012 Jul;194(13):3486-94. doi: 10.1128/JB.00194-12. Epub 2012 Apr 13.
4
Production, purification, sequencing and activity spectra of mutacins D-123.1 and F-59.1.mutacins D-123.1 和 F-59.1 的生产、纯化、测序和活性谱。
BMC Microbiol. 2011 Apr 10;11:69. doi: 10.1186/1471-2180-11-69.
5
Comprehensive analysis of bacteriocins in Streptococcus mutans.全面分析变异链球菌中的细菌素。
Sci Rep. 2021 Jun 21;11(1):12963. doi: 10.1038/s41598-021-92370-1.
6
Identification of nlmTE, the locus encoding the ABC transport system required for export of nonlantibiotic mutacins in Streptococcus mutans.变形链球菌中 nlmTE 的鉴定，nlmTE 是编码非羊毛硫抗生素变链菌素输出所需 ABC 转运系统的基因座。
J Bacteriol. 2005 Jul;187(14):5036-9. doi: 10.1128/JB.187.14.5036-5039.2005.
7
Gene Rearrangement and Modification of Immunity Factors Are Correlated with the Insertion of Bacteriocin Cassettes in Streptococcus mutans.基因重排和免疫因子修饰与细菌素盒在变形链球菌中的插入有关。
Microbiol Spectr. 2022 Jun 29;10(3):e0180621. doi: 10.1128/spectrum.01806-21. Epub 2022 May 23.
8
The specific genes for lantibiotic mutacin II biosynthesis in Streptococcus mutans T8 are clustered and can be transferred en bloc.变形链球菌T8中羊毛硫抗生素变链菌素II生物合成的特定基因成簇存在，且可作为一个整体进行转移。
Appl Environ Microbiol. 1999 Mar;65(3):1356-60. doi: 10.1128/AEM.65.3.1356-1360.1999.
9
Genes involved in the repression of mutacin I production in Streptococcus mutans.参与变形链球菌中变链菌素I产生抑制的基因。
Microbiology (Reading). 2009 Feb;155(Pt 2):551-556. doi: 10.1099/mic.0.021303-0.
10
Frequency of four different mutacin genes in Streptococcus mutans genotypes isolated from caries-free and caries-active individuals.从无龋和患龋个体中分离出的变形链球菌基因型中四种不同变链菌素基因的频率。
J Med Microbiol. 2005 Jun;54(Pt 6):599-604. doi: 10.1099/jmm.0.45870-0.
引用本文的文献
1
Streptococcal natural products mediate interspecies competition with Gram-positive bacterial pathogens.链球菌天然产物介导与革兰氏阳性病原菌的种间竞争。
bioRxiv. 2025 Jul 31:2025.07.31.667707. doi: 10.1101/2025.07.31.667707.
2
SepM mutation in Streptococcus mutans clinical isolates and related function analysis.变形链球菌临床分离株 SepM 突变及相关功能分析。
BMC Oral Health. 2024 Jun 25;24(1):730. doi: 10.1186/s12903-024-04436-x.
3
In Situ Raman Analysis of Biofilm Exopolysaccharides Formed in and Commensal Cultures.原位拉曼分析 和 共生培养物中生物膜胞外多糖的形成。
Int J Mol Sci. 2023 Apr 3;24(7):6694. doi: 10.3390/ijms24076694.
4
Nutritional factors influencing microbiota-mediated colonization resistance of the oral cavity: A literature review.影响微生物群介导的口腔定植抗性的营养因素：文献综述
Front Nutr. 2022 Oct 20;9:1029324. doi: 10.3389/fnut.2022.1029324. eCollection 2022.
5
Oral Commensal Streptococci: Gatekeepers of the Oral Cavity.口腔共生链球菌：口腔的守门员。
J Bacteriol. 2022 Nov 15;204(11):e0025722. doi: 10.1128/jb.00257-22. Epub 2022 Oct 26.
6
and Modulate Production of Mutanocyclin and Reutericyclins in Streptococcus mutans B04Sm5.并调节变形链球菌 B04Sm5 中突变环素和雷替环素的产生。
J Bacteriol. 2022 May 17;204(5):e0004222. doi: 10.1128/jb.00042-22. Epub 2022 Apr 11.
7
Tetramic Acids Mutanocyclin and Reutericyclin A, Produced by Strain B04Sm5 Modulate the Ecology of an Oral Biofilm.由菌株B04Sm5产生的四胺酸类物质变链菌素和罗伊氏菌素A调节口腔生物膜的生态。
Front Oral Health. 2022 Jan 7;2:796140. doi: 10.3389/froh.2021.796140. eCollection 2021.
8
Angicin, a novel bacteriocin of Streptococcus anginosus.咽峡炎链球菌素 Angicin，一种新型的链球菌细菌素。
Sci Rep. 2021 Dec 21;11(1):24377. doi: 10.1038/s41598-021-03797-5.
9
[Association of sepM gene mutation with mutacin Ⅳ production by ].[sepM基因突变与（某种物质）产变链菌素Ⅳ的关联]
你提供的原文不完整，括号里的内容缺失，以上是根据现有内容翻译的。
Nan Fang Yi Ke Da Xue Xue Bao. 2021 Jun 20;41(6):876-882. doi: 10.12122/j.issn.1673-4254.2021.06.10.
10
Mucin O-glycans suppress quorum-sensing pathways and genetic transformation in Streptococcus mutans.粘蛋白 O-聚糖抑制变形链球菌中的群体感应途径和遗传转化。
Nat Microbiol. 2021 May;6(5):574-583. doi: 10.1038/s41564-021-00876-1. Epub 2021 Mar 18.
本文引用的文献
1
ClpP of Streptococcus mutans differentially regulates expression of genomic islands, mutacin production, and antibiotic tolerance.变形链球菌 ClpP 差异调控基因组岛、黏菌素产生和抗生素耐药性表达。
J Bacteriol. 2010 Mar;192(5):1312-23. doi: 10.1128/JB.01350-09. Epub 2009 Dec 28.
2
Peptide alarmone signalling triggers an auto-active bacteriocin necessary for genetic competence.肽警戒素信号传导触发了遗传感受态所必需的一种自激活细菌素。
Mol Microbiol. 2009 May;72(4):905-17. doi: 10.1111/j.1365-2958.2009.06693.x. Epub 2009 Apr 14.
3
Structure-function relationships of the non-lanthionine-containing peptide (class II) bacteriocins produced by gram-positive bacteria.革兰氏阳性菌产生的不含羊毛硫氨酸的肽（II类）细菌素的结构-功能关系
Curr Pharm Biotechnol. 2009 Jan;10(1):19-37. doi: 10.2174/138920109787048661.
4
Markerless multiple-gene-deletion system for Streptococcus mutans.变形链球菌的无标记多基因缺失系统
Appl Environ Microbiol. 2008 Apr;74(7):2037-42. doi: 10.1128/AEM.02346-07. Epub 2008 Feb 8.
5
Bacteria of dental caries in primary and permanent teeth in children and young adults.儿童和年轻成年人乳牙及恒牙中的龋齿细菌。
J Clin Microbiol. 2008 Apr;46(4):1407-17. doi: 10.1128/JCM.01410-07. Epub 2008 Jan 23.
6
Regulation of gbpC expression in Streptococcus mutans.变形链球菌中gbpC表达的调控
J Bacteriol. 2007 Sep;189(18):6521-31. doi: 10.1128/JB.00825-07. Epub 2007 Jul 6.
7
Lantibiotics: peptides of diverse structure and function.羊毛硫抗生素：结构与功能多样的肽类
Annu Rev Microbiol. 2007;61:477-501. doi: 10.1146/annurev.micro.61.080706.093501.
8
Common mechanisms of target cell recognition and immunity for class II bacteriocins.II类细菌素靶细胞识别与免疫的常见机制。
Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2384-9. doi: 10.1073/pnas.0608775104. Epub 2007 Feb 6.
9
Role of bacteriocin immunity proteins in the antimicrobial sensitivity of Streptococcus mutans.细菌素免疫蛋白在变形链球菌抗菌敏感性中的作用
J Bacteriol. 2006 Dec;188(23):8095-102. doi: 10.1128/JB.00908-06. Epub 2006 Sep 22.
10
Bacteriocin (mutacin) production by Streptococcus mutans genome sequence reference strain UA159: elucidation of the antimicrobial repertoire by genetic dissection.变形链球菌基因组序列参考菌株UA159产生细菌素（变链菌素）：通过基因剖析阐明抗菌谱。
Appl Environ Microbiol. 2005 Nov;71(11):7613-7. doi: 10.1128/AEM.71.11.7613-7617.2005.
Zotero 插件