Kühn W, Feichter G E, Beier K, Rummel H H, Abel U, Kaufmann M
Abt. für Gynäkologische Morphologie, Univ.-Frauenklinik Heidelberg.
Geburtshilfe Frauenheilkd. 1990 Aug;50(8):597-604. doi: 10.1055/s-2008-1026308.
There is no agreement in literature on the biological behavior of psammoma carcinomas of the ovary. The majority of authors consider psammoma bodies to be the result of tumour regression, associating the occurrence of psammoma bodies with longer survival. On the other hand, several studies reveal a poor prognosis for psammoma carcinomas, similar to that of other epithelial malignant tumours. In our study, the psammoma body content in 174 serous carcinomas stage III/IV was morphometrically quantified by image analysis and the results correlated to survival time and progression time. In 20 carcinomas the psammoma body content was extremely high. In such cases, DNA flow cytometry revealed these tumours to be slowly-growing. The DNA index was 1.0 (DNA-diploid) and the number of S phases was low (max. 5.9%). The five year estimate survival was 50%, as opposed to 10% for other tumours. If no methods are available for cell kinetic analysis and for objectification and quantification of psammoma body content in serous carcinomas it is sufficient to make a semiquantitative assessment of the psammoma body content to differentiate tumours with longer survival from carcinomas of poor prognosis.
关于卵巢砂粒体癌的生物学行为，文献中尚无定论。大多数作者认为砂粒体是肿瘤消退的结果，将砂粒体的出现与更长的生存期联系起来。另一方面，一些研究表明砂粒体癌的预后较差，与其他上皮性恶性肿瘤相似。在我们的研究中，通过图像分析对174例III/IV期浆液性癌中的砂粒体含量进行了形态计量学量化，并将结果与生存时间和进展时间相关联。在20例癌中，砂粒体含量极高。在这种情况下，DNA流式细胞术显示这些肿瘤生长缓慢。DNA指数为1.0（DNA二倍体），S期细胞数量低（最大5.9%）。五年估计生存率为50%，而其他肿瘤为10%。如果没有细胞动力学分析方法以及浆液性癌中砂粒体含量的客观化和量化方法，对砂粒体含量进行半定量评估足以区分生存期较长的肿瘤和预后较差的癌。
