Bokhari Faraz Ahmed, Shakoori Tania A, Hassan Syed Ahmad A, Qureshi Hamid J, Qureshi Ghulam A
Department of Physiology, University of Health Sciences/Federal Postgraduate Medical Institute, Shaikh Zayed Medical Complex, Lahore, Pakistan.
J Ayub Med Coll Abbottabad. 2010 Apr-Jun;22(2):52-5.
Few studies have studied the role of homocysteine in migraineurs and have produced conflicting results. The MTHFR C677T genotype has been associated with increased risk of migraine in selected clinical samples. We assessed the association of the MTHFR C677T variant with migraine, the corresponding homocysteine levels and their correlation.
We studied 27 random adult migraineurs with aura (MWA), migraine without aura (MWOA), and 32 non-migraineurs (controls) from Lahore, Pakistan in this pilot study which is still under progress.
We found significant differences in homocysteine levels between various diagnostic groups (K-W test: p=0.005). One-way ANOVA, post-hoc tests revealed significant differences in homocysteine levels between Non-migraineurs, MWA (p=0.002, CI: 1.93 - 9.19) and MWoA (p=0.002, CI: -9.19 - -1.9). We found a significant association between the migraine group and C677T-MTHFR variant mutant allele (C/T) (p=0.039). We did not find a significant association between C677T-MTHFR variant and homocysteine levels.
In this pilot study, we found plasma homocysteine levels to be significantly associated with MWOA. Additionally, plasma homocysteine levels were lower in MWA than in MWOA. Furthermore, we did not find a relationship between homocysteine levels and the MTHFR variant (SNP rs1801133). Lastly, there may be a relationship between the MTHFR variant (SNP rs1801133) and migraine in this population.
很少有研究探讨同型半胱氨酸在偏头痛患者中的作用，且结果相互矛盾。在特定临床样本中，MTHFR C677T基因型与偏头痛风险增加有关。我们评估了MTHFR C677T变异与偏头痛、相应的同型半胱氨酸水平及其相关性。
在这项仍在进行的初步研究中，我们对来自巴基斯坦拉合尔的27名随机选取的成年有先兆偏头痛患者（MWA）、无先兆偏头痛患者（MWOA）和32名非偏头痛患者（对照组）进行了研究。
我们发现不同诊断组之间的同型半胱氨酸水平存在显著差异（Kruskal-Wallis检验：p = 0.005）。单因素方差分析及事后检验显示，非偏头痛患者与MWA（p = 0.002，置信区间：1.93 - 9.19）和MWOA（p = 0.002，置信区间：-9.19 - -1.9）之间的同型半胱氨酸水平存在显著差异。我们发现偏头痛组与C677T - MTHFR变异突变等位基因（C/T）之间存在显著关联（p = 0.039）。我们未发现C677T - MTHFR变异与同型半胱氨酸水平之间存在显著关联。
在这项初步研究中，我们发现血浆同型半胱氨酸水平与MWOA显著相关。此外，MWA中的血浆同型半胱氨酸水平低于MWOA。此外，我们未发现同型半胱氨酸水平与MTHFR变异（单核苷酸多态性rs1801133）之间存在关联。最后，在该人群中，MTHFR变异（单核苷酸多态性rs1801133）与偏头痛之间可能存在关联。
