Department of Biotechnology, School of Bioengineering, SRM University, Kattankulathur 603203, Tamil Nadu, India.
J Biomed Nanotechnol. 2011 Apr;7(2):238-44. doi: 10.1166/jbn.2011.1283.
Bone tissue engineering is an interdisciplinary field which is emerged for the development of viable substitutes that restore and maintain the function of human bone tissues. The success of bone tissue engineering depends on designing of the scaffolds. The polymer-based composite scaffolds containing micro- and nano-structures could provide a platform influencing osteoblastic cell adhesion, spreading, proliferation, and differentiation. Osteoblasts may adhere strongly to the nano-structures than micro-structures in the scaffolds due to the large surface area, better osteo-integrative property and mechanical reliability etc. In this review we are focusing the factors such as pore size, surface topography and roughness, protein adsorption and wettability of nano-structures and their interaction with cell surface integrins molecules. A better understanding of the interactions of nano-structures with osteoblastic cells will have potential applications in the regeneration of bone.
骨组织工程是一个多学科领域，其出现是为了开发可行的替代品，以恢复和维持人体骨组织的功能。骨组织工程的成功取决于支架的设计。含有微纳米结构的基于聚合物的复合材料支架可以为影响成骨细胞黏附、铺展、增殖和分化的平台提供影响。由于纳米结构具有较大的表面积、更好的骨整合特性和机械可靠性等，因此成骨细胞在支架中可能比微结构更牢固地黏附在纳米结构上。在这篇综述中，我们关注的因素包括纳米结构的孔径、表面形貌和粗糙度、蛋白质吸附和润湿性及其与细胞表面整合素分子的相互作用。更好地了解纳米结构与成骨细胞的相互作用将在骨再生中有潜在的应用。
