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使用非线性分析方法研究可乐定给药后大鼠药效学脑电图特征的证据。

Evidence of a pharmacodynamic EEG profile in rats following clonidine administration using a nonlinear analysis.

作者信息

Azulay David-Olivier D, Renoux Benjamin, Ivarsson Magnus

机构信息

Pfizer Global Research and Development, Ramsgate Road, Sandwich, CT13 9NJ, UK.

出版信息

Nonlinear Biomed Phys. 2011 Jun 26;5(1):4. doi: 10.1186/1753-4631-5-4.

DOI:10.1186/1753-4631-5-4
PMID:21703022
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3141322/
Abstract

BACKGROUND

Changes caused by clonidine in rodent electroencephalograms (EEG) have been reported with some inconsistency. For this reason, a pre-clinical study was conducted in order to confirm previous findings with both a standard spectral analysis and a sleep stage scoring procedure. In addition, a nonlinear technique for analysing the time-varying signals was implemented to compare its performance against conventional approaches.

RESULTS

The nonlinear method succeeds in quantifying all dose-related responses from the data set relying solely on the EEG trace.

CONCLUSIONS

Nonlinear approaches can deliver a suitable alternative to the sleep-stage scoring methods commonly used for drug effect detection.

摘要

背景

关于可乐定对啮齿动物脑电图（EEG）产生的变化，已有报道存在一些不一致之处。因此，开展了一项临床前研究，以通过标准频谱分析和睡眠阶段评分程序来确认先前的研究结果。此外，还采用了一种用于分析时变信号的非线性技术，以将其性能与传统方法进行比较。

结果

非线性方法仅依靠脑电图记录就成功地从数据集中量化了所有与剂量相关的反应。

结论

非线性方法可以为通常用于药物效应检测的睡眠阶段评分方法提供合适的替代方案。

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Everything you wanted to ask about EEG but were afraid to get the right answer.关于脑电图你想问却又不敢知道正确答案的一切。
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