Department of Psychology, Saint Bonaventure University, 3261 West State Street, Saint Bonaventure, NY 14778, USA.
Behav Brain Funct. 2011 Jun 26;7:21. doi: 10.1186/1744-9081-7-21.
Brain regions that mediate learning of a conditioned place preference (CPP) undergo significant development in pre and periadolescence. Consuming a high fat (HF) diet during this developmental period and into adulthood can lead to learning impairments in rodents. The present study tested whether HF diet intake, consumed only in pre and periadolescence, would be sufficient to cause impairments using a CPP procedure.
Rats were randomly assigned to consume a HF or a low fat (LF) diet during postnatal days (PD) 21-40 and were then placed back on a standard lab chow diet. A 20-day CPP procedure, using HF Cheetos® as the unconditioned stimulus (US), began either the next day (PD 41) or 40 days later (PD 81). A separate group of adult rats were given the HF diet for 20 days beginning on PD 61, and then immediately underwent the 20-day CPP procedure beginning on PD 81.
Pre and periadolescent exposure to a LF diet or adult exposure to a HF diet did not interfere with the development of a HF food-induced CPP, as these groups exhibited robust preferences for the HF Cheetos® food-paired compartment. However, pre and periadolescent exposure to the HF diet impaired the development of a HF food-induced CPP regardless of whether it was assessed immediately or 40 days after the exposure to the HF diet, and despite showing increased consumption of the HF Cheetos® in conditioning.
Intake of a HF diet, consumed only in pre and periadolescence, has long-lasting effects on learning that persist into adulthood.
介导条件性位置偏好（CPP）学习的大脑区域在青春期前和青春期期间经历了显著的发育。在这个发育时期和成年期摄入高脂肪（HF）饮食会导致啮齿动物的学习障碍。本研究测试了仅在青春期前和青春期期间摄入 HF 饮食是否足以通过 CPP 程序引起损伤。
大鼠被随机分配在出生后第 21-40 天期间摄入 HF 或低脂肪（LF）饮食，然后再恢复到标准实验室饲料。使用 HF Cheetos®作为非条件刺激（US）进行为期 20 天的 CPP 程序，要么在第二天（PD41）开始，要么在 40 天后（PD81）开始。另一组成年大鼠从 PD61 开始摄入 HF 饮食 20 天，然后立即从 PD81 开始进行 20 天的 CPP 程序。
青春期前和青春期摄入 LF 饮食或成年期摄入 HF 饮食不会干扰 HF 食物诱导的 CPP 的发展，因为这些组对 HF Cheetos®食物配对隔间表现出强烈的偏好。然而，青春期前和青春期摄入 HF 饮食会损害 HF 食物诱导的 CPP 的发展，无论它是在暴露于 HF 饮食后立即评估还是 40 天后评估，尽管在训练中增加了 HF Cheetos®的摄入量。
仅在青春期前和青春期摄入 HF 饮食会对学习产生持久的影响，这种影响会持续到成年期。
