Lipids and Lipoproteins Laboratory. Department of Clinical Biochemistry, INFIBIOC, Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Argentina.
Clin Chim Acta. 2011 Sep 18;412(19-20):1731-9. doi: 10.1016/j.cca.2011.06.013. Epub 2011 Jun 17.
Experimental and clinical evidence supports the concept that metalloproteinases (MMPs), beyond different physiologic functions, also play a role in the development and rupture of the atherosclerotic plaque. Interest in MMPs has been rapidly increasing during the last years, especially as they have been proposed as biomarkers of vulnerable plaques. Different components of the metabolic syndrome (MS) have been identified as possible stimulus for the synthesis and activity of MMPs, like pro-inflammatory and pro-oxidant state, hyperglycemia, hypertension and dyslipidemia. On the other hand, anti-inflammatory cytokines like adiponectin are inversely associated with MMPs. Among the several MMPs studied, collagenases (MMP-1 and MMP-8) and gelatinases (MMP-2 and MMP-9) are the most associated with MS. Our aim was to summarize and discuss the relation between different components of the MS on MMPs, as well as the effect of the cluster of the metabolic alterations itself. It also highlights the necessity of further studies, in both animals and humans, to elucidate the function of novel MMPs identified, as well as the role of the known enzymes in different steps of metabolic diseases. Understanding the mechanisms of MS impact on MMPs and vice versa is an interesting area of research that will positively enhance our understanding of the complexity of MS and atherosclerosis.
实验和临床证据支持这样一种观点，即金属蛋白酶（MMPs）除了具有不同的生理功能外，还在动脉粥样硬化斑块的发生和破裂中发挥作用。近年来，人们对 MMPs 的兴趣迅速增加，特别是因为它们被提出作为易损斑块的生物标志物。代谢综合征（MS）的不同成分已被确定为 MMPs 合成和活性的可能刺激因素，如促炎和促氧化状态、高血糖、高血压和血脂异常。另一方面，抗炎细胞因子如脂联素与 MMPs 呈负相关。在研究的几种 MMPs 中，胶原酶（MMP-1 和 MMP-8）和明胶酶（MMP-2 和 MMP-9）与 MS 的相关性最强。我们的目的是总结和讨论 MS 的不同成分对 MMPs 的关系，以及代谢改变本身的集群的影响。它还强调了在动物和人类中进一步研究的必要性，以阐明新鉴定的 MMPs 的功能，以及已知酶在代谢疾病不同阶段的作用。了解 MS 对 MMPs 的影响机制以及反之亦然，是一个有趣的研究领域，将有助于我们更好地理解 MS 和动脉粥样硬化的复杂性。
