白细胞介素-16 rs11556218 基因多态性与汉族人群冠心病相关。
IL-16 rs11556218 gene polymorphism is associated with coronary artery disease in the Chinese Han population.
机构信息
Department of Cardiology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, PR China.
Department of Public Management, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, PR China.
出版信息
Clin Biochem. 2011 Sep;44(13):1041-1044. doi: 10.1016/j.clinbiochem.2011.06.010. Epub 2011 Jun 17.
OBJECTIVE
Our aim was to investigate the association between IL-16 gene polymorphisms (rs4778889 C/T and rs11556218 G/T) and coronary artery disease (CAD).
DESIGN AND METHODS
The initial cohort consisted of 300 CAD patients and 397 controls from the Chinese Han population. Genotyping was performed by using polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP). The positive association between polymorphism and CAD was replicated in another independent cohort, which included 424 CAD cases and 332 controls.
RESULTS
In the initial study, the allele and genotype frequencies of rs4778889 were not different between in CAD and controls (P>0.05). However, The G allele frequency of rs11556218 was significantly higher in the CAD cases than in the controls (CAD, 46.8% vs. controls, 22.8%, P<0.001). The risk of CAD was significantly higher in the G allele carriers than in the non-carriers (P<0.001, adjusted odds ratio = 7.27; 95% confidence interval, 4.13-12.8). In the replication cohort, G carriers of rs11556218 also had a higher risk of CAD (P = 0.005, adjusted OR = 2.33; 95% confidence interval, 1.45-3.74).
CONCLUSION
Our study suggested that IL-16 rs11556218 G/T polymorphism is significantly associated with the risk of CAD in the Chinese Han population.
目的
本研究旨在探讨白细胞介素-16（IL-16）基因多态性（rs4778889 C/T 和 rs11556218 G/T）与冠状动脉疾病（CAD）的相关性。
设计与方法
初始队列由 300 例 CAD 患者和 397 例来自汉族人群的对照组成。采用聚合酶链反应（PCR）-限制性片段长度多态性（RFLP）方法进行基因分型。在另一个独立的队列中，对该多态性与 CAD 的阳性关联进行了验证，该队列包括 424 例 CAD 病例和 332 例对照。
结果
在初步研究中，rs4778889 的等位基因和基因型频率在 CAD 患者和对照组之间无差异（P>0.05）。然而，rs11556218 的 G 等位基因频率在 CAD 患者中明显高于对照组（CAD，46.8%；对照组，22.8%，P<0.001）。G 等位基因携带者患 CAD 的风险明显高于非携带者（P<0.001，调整后的比值比=7.27；95%置信区间，4.13-12.8）。在复制队列中，rs11556218 的 G 携带者也具有更高的 CAD 风险（P=0.005，调整后的 OR=2.33；95%置信区间，1.45-3.74）。
结论
本研究表明，IL-16 rs11556218 G/T 多态性与汉族人群 CAD 风险显著相关。
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